Brain-immune interaction accompanying odor-evoked autobiographic memory.
The phenomenon in which a certain smell evokes a specific memory is known as the Proust phenomenon. Odor-evoked autobiographic memories are more emotional than those elicited by other sensory stimuli. The results of our previous study indicated that odor-evoked autobiographic memory accompanied by p...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3748042?pdf=render |
| _version_ | 1818700661759410176 |
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| author | Masahiro Matsunaga Yu Bai Kaori Yamakawa Asako Toyama Mitsuyoshi Kashiwagi Kazuyuki Fukuda Akiko Oshida Kazue Sanada Seisuke Fukuyama Jun Shinoda Jitsuhiro Yamada Norihiro Sadato Hideki Ohira |
| author_facet | Masahiro Matsunaga Yu Bai Kaori Yamakawa Asako Toyama Mitsuyoshi Kashiwagi Kazuyuki Fukuda Akiko Oshida Kazue Sanada Seisuke Fukuyama Jun Shinoda Jitsuhiro Yamada Norihiro Sadato Hideki Ohira |
| author_sort | Masahiro Matsunaga |
| collection | DOAJ |
| description | The phenomenon in which a certain smell evokes a specific memory is known as the Proust phenomenon. Odor-evoked autobiographic memories are more emotional than those elicited by other sensory stimuli. The results of our previous study indicated that odor-evoked autobiographic memory accompanied by positive emotions has remarkable effects on various psychological and physiological activities, including the secretion of cytokines, which are immune-signaling molecules that modulate systemic inflammation. In this study, we aimed to clarify the neural substrates associated with the interaction between odor-evoked autobiographic memory and peripheral circulating cytokines. We recruited healthy male and female volunteers and investigated the association between brain responses and the concentration of several cytokines in the plasma by using positron emission tomography (PET) recordings when an autographic memory was evoked in participants by asking them to smell an odor that was nostalgic to them. Participants experienced positive emotions and autobiographic memories when nostalgic odors were presented to them. The levels of peripheral proinflammatory cytokines, such as the tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), were significantly reduced after experiencing odor-evoked autobiographic memory. Subtraction analysis of PET images indicated that the medial orbitofrontal cortex (mOFC) and precuneus/posterior cingulate cortex (PCC) were significantly activated during experiences of odor-evoked autobiographic memory. Furthermore, a correlation analysis indicated that activities of the mOFC and precuneus/PCC were negatively correlated with IFN-γ concentration. These results indicate that the neural networks including the precuneus/PCC and mOFC might regulate the secretion of peripheral proinflammatory cytokines during the experience of odor-evoked autobiographic memories accompanied with positive emotions. |
| first_indexed | 2024-12-17T15:08:30Z |
| format | Article |
| id | doaj.art-b7a15092e2a94aa2815376961adcd1d8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T15:08:30Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b7a15092e2a94aa2815376961adcd1d82022-12-21T21:43:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7252310.1371/journal.pone.0072523Brain-immune interaction accompanying odor-evoked autobiographic memory.Masahiro MatsunagaYu BaiKaori YamakawaAsako ToyamaMitsuyoshi KashiwagiKazuyuki FukudaAkiko OshidaKazue SanadaSeisuke FukuyamaJun ShinodaJitsuhiro YamadaNorihiro SadatoHideki OhiraThe phenomenon in which a certain smell evokes a specific memory is known as the Proust phenomenon. Odor-evoked autobiographic memories are more emotional than those elicited by other sensory stimuli. The results of our previous study indicated that odor-evoked autobiographic memory accompanied by positive emotions has remarkable effects on various psychological and physiological activities, including the secretion of cytokines, which are immune-signaling molecules that modulate systemic inflammation. In this study, we aimed to clarify the neural substrates associated with the interaction between odor-evoked autobiographic memory and peripheral circulating cytokines. We recruited healthy male and female volunteers and investigated the association between brain responses and the concentration of several cytokines in the plasma by using positron emission tomography (PET) recordings when an autographic memory was evoked in participants by asking them to smell an odor that was nostalgic to them. Participants experienced positive emotions and autobiographic memories when nostalgic odors were presented to them. The levels of peripheral proinflammatory cytokines, such as the tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), were significantly reduced after experiencing odor-evoked autobiographic memory. Subtraction analysis of PET images indicated that the medial orbitofrontal cortex (mOFC) and precuneus/posterior cingulate cortex (PCC) were significantly activated during experiences of odor-evoked autobiographic memory. Furthermore, a correlation analysis indicated that activities of the mOFC and precuneus/PCC were negatively correlated with IFN-γ concentration. These results indicate that the neural networks including the precuneus/PCC and mOFC might regulate the secretion of peripheral proinflammatory cytokines during the experience of odor-evoked autobiographic memories accompanied with positive emotions.http://europepmc.org/articles/PMC3748042?pdf=render |
| spellingShingle | Masahiro Matsunaga Yu Bai Kaori Yamakawa Asako Toyama Mitsuyoshi Kashiwagi Kazuyuki Fukuda Akiko Oshida Kazue Sanada Seisuke Fukuyama Jun Shinoda Jitsuhiro Yamada Norihiro Sadato Hideki Ohira Brain-immune interaction accompanying odor-evoked autobiographic memory. PLoS ONE |
| title | Brain-immune interaction accompanying odor-evoked autobiographic memory. |
| title_full | Brain-immune interaction accompanying odor-evoked autobiographic memory. |
| title_fullStr | Brain-immune interaction accompanying odor-evoked autobiographic memory. |
| title_full_unstemmed | Brain-immune interaction accompanying odor-evoked autobiographic memory. |
| title_short | Brain-immune interaction accompanying odor-evoked autobiographic memory. |
| title_sort | brain immune interaction accompanying odor evoked autobiographic memory |
| url | http://europepmc.org/articles/PMC3748042?pdf=render |
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