Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus
The production of oxygen free radicals in type 2 diabetes mellitus contributes to the development of complications, especially the cardiovascular-related ones. Peroxiredoxins (PRDXs) are antioxidant enzymes that combat oxidative stress. The aim of this study was to investigate the associations betwe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2015-03-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/bjmbr/v48n5/1414-431X-bjmbr-1414-431X20144142.pdf |
| _version_ | 1818743521590378496 |
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| author | E. El Eter A.A. Al-Masri |
| author_facet | E. El Eter A.A. Al-Masri |
| author_sort | E. El Eter |
| collection | DOAJ |
| description | The production of oxygen free radicals in type 2 diabetes mellitus contributes to the development of complications, especially the cardiovascular-related ones. Peroxiredoxins (PRDXs) are antioxidant enzymes that combat oxidative stress. The aim of this study was to investigate the associations between the levels of PRDX isoforms (1, 2, 4, and 6) and cardiovascular risk factors in type 2 diabetes mellitus. Fifty-three patients with type 2 diabetes mellitus (28F/25M) and 25 healthy control subjects (7F/18M) were enrolled. We measured the plasma levels of each PRDX isoform and analyzed their correlations with cardiovascular risk factors. The plasma PRDX1, -2, -4, and -6 levels were higher in the diabetic patients than in the healthy control subjects. PRDX2 and -6 levels were negatively correlated with diastolic blood pressure, fasting blood sugar, and hemoglobin A1c. In contrast, PRDX1 levels were positively correlated with low-density lipoprotein and C-reactive protein levels. PRDX4 levels were negatively correlated with triglycerides. In conclusion, PRDX1, -2, -4, and -6 showed differential correlations with a variety of traditional cardiovascular risk factors. These results should encourage further research into the crosstalk between PRDX isoforms and cardiovascular risk factors. |
| first_indexed | 2024-12-18T02:29:44Z |
| format | Article |
| id | doaj.art-b7a1c04d42b24429ae0f1a34c55c2f61 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-18T02:29:44Z |
| publishDate | 2015-03-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-b7a1c04d42b24429ae0f1a34c55c2f612022-12-21T21:23:57ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2015-03-0148546546910.1590/1414-431x20144142Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitusE. El EterA.A. Al-MasriThe production of oxygen free radicals in type 2 diabetes mellitus contributes to the development of complications, especially the cardiovascular-related ones. Peroxiredoxins (PRDXs) are antioxidant enzymes that combat oxidative stress. The aim of this study was to investigate the associations between the levels of PRDX isoforms (1, 2, 4, and 6) and cardiovascular risk factors in type 2 diabetes mellitus. Fifty-three patients with type 2 diabetes mellitus (28F/25M) and 25 healthy control subjects (7F/18M) were enrolled. We measured the plasma levels of each PRDX isoform and analyzed their correlations with cardiovascular risk factors. The plasma PRDX1, -2, -4, and -6 levels were higher in the diabetic patients than in the healthy control subjects. PRDX2 and -6 levels were negatively correlated with diastolic blood pressure, fasting blood sugar, and hemoglobin A1c. In contrast, PRDX1 levels were positively correlated with low-density lipoprotein and C-reactive protein levels. PRDX4 levels were negatively correlated with triglycerides. In conclusion, PRDX1, -2, -4, and -6 showed differential correlations with a variety of traditional cardiovascular risk factors. These results should encourage further research into the crosstalk between PRDX isoforms and cardiovascular risk factors.http://www.scielo.br/pdf/bjmbr/v48n5/1414-431X-bjmbr-1414-431X20144142.pdfPeroxiredoxinsType 2 diabetes mellitusOxidative stressCardiovascular risk factors |
| spellingShingle | E. El Eter A.A. Al-Masri Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus Brazilian Journal of Medical and Biological Research Peroxiredoxins Type 2 diabetes mellitus Oxidative stress Cardiovascular risk factors |
| title | Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus |
| title_full | Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus |
| title_fullStr | Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus |
| title_full_unstemmed | Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus |
| title_short | Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus |
| title_sort | peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus |
| topic | Peroxiredoxins Type 2 diabetes mellitus Oxidative stress Cardiovascular risk factors |
| url | http://www.scielo.br/pdf/bjmbr/v48n5/1414-431X-bjmbr-1414-431X20144142.pdf |
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