Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review
The treatment of cancers is a significant challenge in the healthcare context today. Spreading circulating tumor cells (CTCs) throughout the body will eventually lead to cancer metastasis and produce new tumors near the healthy tissues. Therefore, separating these invading cells and extracting cues...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/23/11/5300 |
| _version_ | 1797596716323569664 |
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| author | Alireza Farahinia Wenjun Zhang Ildiko Badea |
| author_facet | Alireza Farahinia Wenjun Zhang Ildiko Badea |
| author_sort | Alireza Farahinia |
| collection | DOAJ |
| description | The treatment of cancers is a significant challenge in the healthcare context today. Spreading circulating tumor cells (CTCs) throughout the body will eventually lead to cancer metastasis and produce new tumors near the healthy tissues. Therefore, separating these invading cells and extracting cues from them is extremely important for determining the rate of cancer progression inside the body and for the development of individualized treatments, especially at the beginning of the metastasis process. The continuous and fast separation of CTCs has recently been achieved using numerous separation techniques, some of which involve multiple high-level operational protocols. Although a simple blood test can detect the presence of CTCs in the blood circulation system, the detection is still restricted due to the scarcity and heterogeneity of CTCs. The development of more reliable and effective techniques is thus highly desired. The technology of microfluidic devices is promising among many other bio-chemical and bio-physical technologies. This paper reviews recent developments in the two types of microfluidic devices, which are based on the size and/or density of cells, for separating cancer cells. The goal of this review is to identify knowledge or technology gaps and to suggest future works. |
| first_indexed | 2024-03-11T02:57:00Z |
| format | Article |
| id | doaj.art-b7a24ded8bb34e2f877414d4f21f79c8 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-11T02:57:00Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-b7a24ded8bb34e2f877414d4f21f79c82023-11-18T08:35:18ZengMDPI AGSensors1424-82202023-06-012311530010.3390/s23115300Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A ReviewAlireza Farahinia0Wenjun Zhang1Ildiko Badea2Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, CanadaDepartment of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, CanadaCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, CanadaThe treatment of cancers is a significant challenge in the healthcare context today. Spreading circulating tumor cells (CTCs) throughout the body will eventually lead to cancer metastasis and produce new tumors near the healthy tissues. Therefore, separating these invading cells and extracting cues from them is extremely important for determining the rate of cancer progression inside the body and for the development of individualized treatments, especially at the beginning of the metastasis process. The continuous and fast separation of CTCs has recently been achieved using numerous separation techniques, some of which involve multiple high-level operational protocols. Although a simple blood test can detect the presence of CTCs in the blood circulation system, the detection is still restricted due to the scarcity and heterogeneity of CTCs. The development of more reliable and effective techniques is thus highly desired. The technology of microfluidic devices is promising among many other bio-chemical and bio-physical technologies. This paper reviews recent developments in the two types of microfluidic devices, which are based on the size and/or density of cells, for separating cancer cells. The goal of this review is to identify knowledge or technology gaps and to suggest future works.https://www.mdpi.com/1424-8220/23/11/5300circulating tumor cells (CTCs)cancer metastasiscell enrichmentcancer diagnosismicrofluidic-based cell separation approacheslab-on-a-chip (LOC) |
| spellingShingle | Alireza Farahinia Wenjun Zhang Ildiko Badea Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review Sensors circulating tumor cells (CTCs) cancer metastasis cell enrichment cancer diagnosis microfluidic-based cell separation approaches lab-on-a-chip (LOC) |
| title | Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review |
| title_full | Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review |
| title_fullStr | Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review |
| title_full_unstemmed | Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review |
| title_short | Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review |
| title_sort | recent developments in inertial and centrifugal microfluidic systems along with the involved forces for cancer cell separation a review |
| topic | circulating tumor cells (CTCs) cancer metastasis cell enrichment cancer diagnosis microfluidic-based cell separation approaches lab-on-a-chip (LOC) |
| url | https://www.mdpi.com/1424-8220/23/11/5300 |
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