Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders
PurposeTo investigate the clinical characteristics of late-onset epilepsy combined with autism spectrum disorder (ASD), and the relationship between certain types of electroencephalography (EEG) abnormalities in ASD and associated neuropsychological problems.MethodsThirty patients diagnosed with ASD...
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| Format: | Article |
| Language: | English |
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Korean Pediatric Society
2011-01-01
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| Series: | Korean Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://kjp.or.kr/upload/pdf/kjped-54-22.pdf |
| _version_ | 1828380622936080384 |
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| author | Haneul Lee Hoon Chul Kang Seung Woo Kim Young Key Kim Hee Jung Chung |
| author_facet | Haneul Lee Hoon Chul Kang Seung Woo Kim Young Key Kim Hee Jung Chung |
| author_sort | Haneul Lee |
| collection | DOAJ |
| description | PurposeTo investigate the clinical characteristics of late-onset epilepsy combined with autism spectrum disorder (ASD), and the relationship between certain types of electroencephalography (EEG) abnormalities in ASD and associated neuropsychological problems.MethodsThirty patients diagnosed with ASD in early childhood and later developed clinical seizures were reviewed retrospectively. First, the clinical characteristics, language and behavioral regression, and EEG findings of these late-onset epilepsy patients with ASD were investigated. The patients were then classified into 2 groups according to the severity of the EEG abnormalities in the background rhythm and paroxysmal discharges. In the severe group, EEG showed persistent asymmetry, slow and disorganized background rhythms, and continuous sharp and slow waves during slow sleep (CSWS).ResultsBetween the two groups, there was no statistically significant difference in mean age (P=0.259), age of epilepsy diagnosis (P=0.237), associated family history (P=0.074), and positive abnormal magnetic resonance image (MRI) findings (P=0.084). The severe EEG group tended to have more neuropsychological problems (P=0.074). The severe group statistically showed more electrographic seizures in EEG (P=0.000). Rett syndrome was correlated with more severe EEG abnormalities (P=0.002). Although formal cognitive function tests were not performed, the parents reported an improvement in neuropsychological function on the follow up checkup according to a parent's questionnaire.ConclusionAlthough some ASD patients with late-onset epilepsy showed severe EEG abnormalities, including CSWS, they generally showed an improvement in EEG and clinical symptoms in the long-term follow up. In addition, severe EEG abnormalities tended to be related to the neuropsychological function. |
| first_indexed | 2024-12-10T04:01:27Z |
| format | Article |
| id | doaj.art-b7a3bd82853a430c9f064164b5561450 |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-12-10T04:01:27Z |
| publishDate | 2011-01-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-b7a3bd82853a430c9f064164b55614502022-12-22T02:02:58ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582011-01-01541222810.3345/kjp.2011.54.1.222011540105Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disordersHaneul Lee0Hoon Chul Kang1Seung Woo Kim2Young Key Kim3Hee Jung Chung4Department of Pediatrics, Pediatric Epilepsy Clinics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.Department of Pediatrics, Pediatric Epilepsy Clinics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.Department of Rehabilitation Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.Department of Child Psychiatry, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.PurposeTo investigate the clinical characteristics of late-onset epilepsy combined with autism spectrum disorder (ASD), and the relationship between certain types of electroencephalography (EEG) abnormalities in ASD and associated neuropsychological problems.MethodsThirty patients diagnosed with ASD in early childhood and later developed clinical seizures were reviewed retrospectively. First, the clinical characteristics, language and behavioral regression, and EEG findings of these late-onset epilepsy patients with ASD were investigated. The patients were then classified into 2 groups according to the severity of the EEG abnormalities in the background rhythm and paroxysmal discharges. In the severe group, EEG showed persistent asymmetry, slow and disorganized background rhythms, and continuous sharp and slow waves during slow sleep (CSWS).ResultsBetween the two groups, there was no statistically significant difference in mean age (P=0.259), age of epilepsy diagnosis (P=0.237), associated family history (P=0.074), and positive abnormal magnetic resonance image (MRI) findings (P=0.084). The severe EEG group tended to have more neuropsychological problems (P=0.074). The severe group statistically showed more electrographic seizures in EEG (P=0.000). Rett syndrome was correlated with more severe EEG abnormalities (P=0.002). Although formal cognitive function tests were not performed, the parents reported an improvement in neuropsychological function on the follow up checkup according to a parent's questionnaire.ConclusionAlthough some ASD patients with late-onset epilepsy showed severe EEG abnormalities, including CSWS, they generally showed an improvement in EEG and clinical symptoms in the long-term follow up. In addition, severe EEG abnormalities tended to be related to the neuropsychological function.http://kjp.or.kr/upload/pdf/kjped-54-22.pdfAutism spectrum disorderEpilepsyElectroencephalographyRegressionChild |
| spellingShingle | Haneul Lee Hoon Chul Kang Seung Woo Kim Young Key Kim Hee Jung Chung Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders Korean Journal of Pediatrics Autism spectrum disorder Epilepsy Electroencephalography Regression Child |
| title | Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders |
| title_full | Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders |
| title_fullStr | Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders |
| title_full_unstemmed | Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders |
| title_short | Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders |
| title_sort | characteristics of late onset epilepsy and eeg findings in children with autism spectrum disorders |
| topic | Autism spectrum disorder Epilepsy Electroencephalography Regression Child |
| url | http://kjp.or.kr/upload/pdf/kjped-54-22.pdf |
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