Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function

Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function

Dopamine system dysfunction is implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive symptoms remain unresponsive and novel paradigms investigating the circuit substrates underlying cognitive deficits are critically need...

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Bibliographic Details
Main Authors: Surjeet Mastwal, Xinjian Li, Rianne Stowell, Matthew Manion, Wenyu Zhang, Nam-Shik Kim, Ki-Jun Yoon, Hongjun Song, Guo-Li Ming, Kuan Hong Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-10-01
Series:eLife
Subjects:
adolescence
dopamine circuit
frontal cortex
chemogenetic
optogenetic
cognitive deficits
Online Access:https://elifesciences.org/articles/87414

Internet

https://elifesciences.org/articles/87414

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