Effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: a systematic review
Abstract Background Oral mucositis remains a significant complication during cancer therapy with no effective treatment. Gold nanoparticles offer anti-inflammatory, antioxidant properties with low toxicity. This study systematically reviews the literature assessing gold nanoparticles in the manageme...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Systematic Reviews |
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| Online Access: | https://doi.org/10.1186/s13643-023-02425-9 |
| _version_ | 1797276700790226944 |
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| author | Minati Choudhury Paul Brunton Donald Schwass Daniel Pletzer Jithendra Ratnayake George Dias Geoffrey Tompkins |
| author_facet | Minati Choudhury Paul Brunton Donald Schwass Daniel Pletzer Jithendra Ratnayake George Dias Geoffrey Tompkins |
| author_sort | Minati Choudhury |
| collection | DOAJ |
| description | Abstract Background Oral mucositis remains a significant complication during cancer therapy with no effective treatment. Gold nanoparticles offer anti-inflammatory, antioxidant properties with low toxicity. This study systematically reviews the literature assessing gold nanoparticles in the management of oral mucositis in animal models. Methods A literature search was undertaken using MEDLINE, Embase, PubMed, and Web of Science databases, using the format for Systematic Review Centre for Laboratory Animal Experimentation. Prior to the review, the protocol was registered in the systematic review register, PROSPERO (registration no. CRD42021272169). Outcome measures included ulceration, histopathological scores, inflammatory mediators, microbial growth, and pain. Study quality was analysed by SYRCLE risk-of-bias tool. Results Only one study met the inclusion criteria, documenting reduction in ulceration, inflammatory, and oxidative biomarkers. Exposure to AuNPs prevented inflammatory response induced by 5-fluorouracil in oral mucosa of hamsters. However, a high risk of bias necessitates further research. Conclusion This review identifies a potential therapeutic strategy for prevention and management of oral mucositis. It also provides future direction for gold nanoparticle research in oral mucositis; however, there is lack of sufficient evidence to derive any conclusion. Research with standardized parameters including nanoparticle size, capping agent, surface charge, and appropriate oral mucositis animal models will establish risk–benefit balance and margin of safety for therapeutic use of gold nanoparticles for oral mucositis. |
| first_indexed | 2024-03-07T15:32:58Z |
| format | Article |
| id | doaj.art-b7a6c72c7ace452b9e165451fb58f6ab |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-03-07T15:32:58Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-b7a6c72c7ace452b9e165451fb58f6ab2024-03-05T16:21:33ZengBMCSystematic Reviews2046-40532024-01-011311810.1186/s13643-023-02425-9Effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: a systematic reviewMinati Choudhury0Paul Brunton1Donald Schwass2Daniel Pletzer3Jithendra Ratnayake4George Dias5Geoffrey Tompkins6Sir John Walsh Research Institute, Faculty of Dentistry, University of OtagoSir John Walsh Research Institute, Faculty of Dentistry, University of OtagoDepartment of Oral Rehabilitation, Faculty of Dentistry, University of OtagoDepartment of Microbiology and Immunology, University of OtagoDepartment of Oral Sciences, Faculty of Dentistry, University of OtagoDepartment of Anatomy, University of OtagoSir John Walsh Research Institute, Faculty of Dentistry, University of OtagoAbstract Background Oral mucositis remains a significant complication during cancer therapy with no effective treatment. Gold nanoparticles offer anti-inflammatory, antioxidant properties with low toxicity. This study systematically reviews the literature assessing gold nanoparticles in the management of oral mucositis in animal models. Methods A literature search was undertaken using MEDLINE, Embase, PubMed, and Web of Science databases, using the format for Systematic Review Centre for Laboratory Animal Experimentation. Prior to the review, the protocol was registered in the systematic review register, PROSPERO (registration no. CRD42021272169). Outcome measures included ulceration, histopathological scores, inflammatory mediators, microbial growth, and pain. Study quality was analysed by SYRCLE risk-of-bias tool. Results Only one study met the inclusion criteria, documenting reduction in ulceration, inflammatory, and oxidative biomarkers. Exposure to AuNPs prevented inflammatory response induced by 5-fluorouracil in oral mucosa of hamsters. However, a high risk of bias necessitates further research. Conclusion This review identifies a potential therapeutic strategy for prevention and management of oral mucositis. It also provides future direction for gold nanoparticle research in oral mucositis; however, there is lack of sufficient evidence to derive any conclusion. Research with standardized parameters including nanoparticle size, capping agent, surface charge, and appropriate oral mucositis animal models will establish risk–benefit balance and margin of safety for therapeutic use of gold nanoparticles for oral mucositis.https://doi.org/10.1186/s13643-023-02425-9Gold nanoparticlesOral mucositisAnimal modelSystematic review |
| spellingShingle | Minati Choudhury Paul Brunton Donald Schwass Daniel Pletzer Jithendra Ratnayake George Dias Geoffrey Tompkins Effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: a systematic review Systematic Reviews Gold nanoparticles Oral mucositis Animal model Systematic review |
| title | Effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: a systematic review |
| title_full | Effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: a systematic review |
| title_fullStr | Effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: a systematic review |
| title_full_unstemmed | Effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: a systematic review |
| title_short | Effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: a systematic review |
| title_sort | effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models a systematic review |
| topic | Gold nanoparticles Oral mucositis Animal model Systematic review |
| url | https://doi.org/10.1186/s13643-023-02425-9 |
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