Genomic epidemiology of Vibrio cholerae during a mass vaccination campaign of displaced communities in Bangladesh
Abstract Ongoing diarrheal disease surveillance throughout Bangladesh over the last decade has revealed seasonal localised cholera outbreaks in Cox’s Bazar, where both Bangladeshi Nationals and Forcibly Displaced Myanmar Nationals (FDMNs) reside in densely populated settlements. FDMNs were recently...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-39415-3 |
| _version_ | 1827916917501853696 |
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| author | Alyce Taylor-Brown Mokibul Hassan Afrad Ashraful Islam Khan Florent Lassalle Md. Taufiqul Islam Nabid Anjum Tanvir Nicholas R. Thomson Firdausi Qadri |
| author_facet | Alyce Taylor-Brown Mokibul Hassan Afrad Ashraful Islam Khan Florent Lassalle Md. Taufiqul Islam Nabid Anjum Tanvir Nicholas R. Thomson Firdausi Qadri |
| author_sort | Alyce Taylor-Brown |
| collection | DOAJ |
| description | Abstract Ongoing diarrheal disease surveillance throughout Bangladesh over the last decade has revealed seasonal localised cholera outbreaks in Cox’s Bazar, where both Bangladeshi Nationals and Forcibly Displaced Myanmar Nationals (FDMNs) reside in densely populated settlements. FDMNs were recently targeted for the largest cholera vaccination campaign in decades. We aimed to infer the epidemic risk of circulating Vibrio cholerae strains by determining if isolates linked to the ongoing global cholera pandemic (“7PET” lineage) were responsible for outbreaks in Cox’s Bazar. We found two sublineages of 7PET in this setting during the study period; one with global distribution, and a second lineage restricted to Asia and the Middle East. These subclades were associated with different disease patterns that could be partially explained by genomic differences. Here we show that as the pandemic V. cholerae lineage circulates in this vulnerable population, without a vaccine intervention, the risk of an epidemic was very high. |
| first_indexed | 2024-03-13T03:20:27Z |
| format | Article |
| id | doaj.art-b7a73cbcff524a85a9f13f01f87102d5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-13T03:20:27Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b7a73cbcff524a85a9f13f01f87102d52023-06-25T11:21:28ZengNature PortfolioNature Communications2041-17232023-06-0114111110.1038/s41467-023-39415-3Genomic epidemiology of Vibrio cholerae during a mass vaccination campaign of displaced communities in BangladeshAlyce Taylor-Brown0Mokibul Hassan Afrad1Ashraful Islam Khan2Florent Lassalle3Md. Taufiqul Islam4Nabid Anjum Tanvir5Nicholas R. Thomson6Firdausi Qadri7Parasites & Microbes Programme, Wellcome Sanger Institute, Wellcome Genome CampusInfectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)Parasites & Microbes Programme, Wellcome Sanger Institute, Wellcome Genome CampusInfectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)Parasites & Microbes Programme, Wellcome Sanger Institute, Wellcome Genome CampusInfectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)Abstract Ongoing diarrheal disease surveillance throughout Bangladesh over the last decade has revealed seasonal localised cholera outbreaks in Cox’s Bazar, where both Bangladeshi Nationals and Forcibly Displaced Myanmar Nationals (FDMNs) reside in densely populated settlements. FDMNs were recently targeted for the largest cholera vaccination campaign in decades. We aimed to infer the epidemic risk of circulating Vibrio cholerae strains by determining if isolates linked to the ongoing global cholera pandemic (“7PET” lineage) were responsible for outbreaks in Cox’s Bazar. We found two sublineages of 7PET in this setting during the study period; one with global distribution, and a second lineage restricted to Asia and the Middle East. These subclades were associated with different disease patterns that could be partially explained by genomic differences. Here we show that as the pandemic V. cholerae lineage circulates in this vulnerable population, without a vaccine intervention, the risk of an epidemic was very high.https://doi.org/10.1038/s41467-023-39415-3 |
| spellingShingle | Alyce Taylor-Brown Mokibul Hassan Afrad Ashraful Islam Khan Florent Lassalle Md. Taufiqul Islam Nabid Anjum Tanvir Nicholas R. Thomson Firdausi Qadri Genomic epidemiology of Vibrio cholerae during a mass vaccination campaign of displaced communities in Bangladesh Nature Communications |
| title | Genomic epidemiology of Vibrio cholerae during a mass vaccination campaign of displaced communities in Bangladesh |
| title_full | Genomic epidemiology of Vibrio cholerae during a mass vaccination campaign of displaced communities in Bangladesh |
| title_fullStr | Genomic epidemiology of Vibrio cholerae during a mass vaccination campaign of displaced communities in Bangladesh |
| title_full_unstemmed | Genomic epidemiology of Vibrio cholerae during a mass vaccination campaign of displaced communities in Bangladesh |
| title_short | Genomic epidemiology of Vibrio cholerae during a mass vaccination campaign of displaced communities in Bangladesh |
| title_sort | genomic epidemiology of vibrio cholerae during a mass vaccination campaign of displaced communities in bangladesh |
| url | https://doi.org/10.1038/s41467-023-39415-3 |
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