Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults
Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the as- sumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles connecting subcortical nuclei and frontal ar- eas and obtain site-specifi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-05-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00081/full |
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| author | Alexandra eVik Alexandra eVik Erlend eHodneland Judit eHaász Judit eHaász Judit eHaász Martin eYstad Astri Johansen Lundervold Astri Johansen Lundervold Arvid eLundervold Arvid eLundervold |
| author_facet | Alexandra eVik Alexandra eVik Erlend eHodneland Judit eHaász Judit eHaász Judit eHaász Martin eYstad Astri Johansen Lundervold Astri Johansen Lundervold Arvid eLundervold Arvid eLundervold |
| author_sort | Alexandra eVik |
| collection | DOAJ |
| description | Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the as- sumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles connecting subcortical nuclei and frontal ar- eas and obtain site-specific information about age related fractional anisotropy (FA) changes. Multimodal magnetic resonance image acquisitions (3D T1-weighted and diffusion weighted imaging (DWI)) were obtained from healthy older adults (N=76, range 49-80 years at inclusion) at two time points, three years apart. A subset of the participants (N=24) was included at a third time-point. In addition to the frontal-subcortical fibers, the anterior callosal fiber (ACF) and the corticospinal tract (CST) was investigated by its mean FA together with tract parameterization analysis. Our results demonstrated fronto-striatal structural connec- tivity decline (reduced FA) in normal aging with substantial inter-individual differences. The tract parameterization analysis showed that the along tract FA profiles were characterized by piece-wise differential changes along their extension rather than being uniformly affected. To the best of our knowledge, this is the first longitudinal study detecting age-related changes in frontal-subcortical WM connections in normal aging. |
| first_indexed | 2024-04-13T19:11:36Z |
| format | Article |
| id | doaj.art-b7ab1a1e063a4fd08de4da8102a6d96c |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T19:11:36Z |
| publishDate | 2015-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-b7ab1a1e063a4fd08de4da8102a6d96c2022-12-22T02:33:49ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-05-01710.3389/fnagi.2015.00081108060Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adultsAlexandra eVik0Alexandra eVik1Erlend eHodneland2Judit eHaász3Judit eHaász4Judit eHaász5Martin eYstad6Astri Johansen Lundervold7Astri Johansen Lundervold8Arvid eLundervold9Arvid eLundervold10University of BergenUniversity of BergenUniversity of BergenUniversity of BergenUniversity of BergenUniversity of BergenUniversity of BergenUniversity of BergenKavli Research center of aging and dementia , Haraldsplass Deaconess HospitalUniversity of BergenHaukeland University HospitalMotivated by the frontal- and white matter (WM) retrogenesis hypotheses and the as- sumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles connecting subcortical nuclei and frontal ar- eas and obtain site-specific information about age related fractional anisotropy (FA) changes. Multimodal magnetic resonance image acquisitions (3D T1-weighted and diffusion weighted imaging (DWI)) were obtained from healthy older adults (N=76, range 49-80 years at inclusion) at two time points, three years apart. A subset of the participants (N=24) was included at a third time-point. In addition to the frontal-subcortical fibers, the anterior callosal fiber (ACF) and the corticospinal tract (CST) was investigated by its mean FA together with tract parameterization analysis. Our results demonstrated fronto-striatal structural connec- tivity decline (reduced FA) in normal aging with substantial inter-individual differences. The tract parameterization analysis showed that the along tract FA profiles were characterized by piece-wise differential changes along their extension rather than being uniformly affected. To the best of our knowledge, this is the first longitudinal study detecting age-related changes in frontal-subcortical WM connections in normal aging.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00081/fulltractographyDiffusion Weighted Imagingfractional anisotropyhealthy aginglongitudinal study3D MRI |
| spellingShingle | Alexandra eVik Alexandra eVik Erlend eHodneland Judit eHaász Judit eHaász Judit eHaász Martin eYstad Astri Johansen Lundervold Astri Johansen Lundervold Arvid eLundervold Arvid eLundervold Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults Frontiers in Aging Neuroscience tractography Diffusion Weighted Imaging fractional anisotropy healthy aging longitudinal study 3D MRI |
| title | Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults |
| title_full | Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults |
| title_fullStr | Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults |
| title_full_unstemmed | Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults |
| title_short | Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults |
| title_sort | fractional anisotropy shows differential reduction in frontal subcortical fiber bundles a longitudinal mri study of 76 middle aged and older adults |
| topic | tractography Diffusion Weighted Imaging fractional anisotropy healthy aging longitudinal study 3D MRI |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00081/full |
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