Disseminated Nocardiosis in Kidney Transplant Recipients: A Report of 2 Cases
Nocardiosis is a rare, life-threatening opportunistic infection caused by bacteria in the environment that predominantly affects immunocompromised patients. Nocardiosis most commonly involves the lungs but can disseminate to other organs. Disseminated nocardiosis, defined as Nocardia infection invol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | Kidney Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059522001777 |
| _version_ | 1797987519523979264 |
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| author | Alissar El Chediak Jefferson L. Triozzi Heidi Schaefer Saed Shawar |
| author_facet | Alissar El Chediak Jefferson L. Triozzi Heidi Schaefer Saed Shawar |
| author_sort | Alissar El Chediak |
| collection | DOAJ |
| description | Nocardiosis is a rare, life-threatening opportunistic infection caused by bacteria in the environment that predominantly affects immunocompromised patients. Nocardiosis most commonly involves the lungs but can disseminate to other organs. Disseminated nocardiosis, defined as Nocardia infection involving 2 or more organ systems, requires early detection and treatment because of high morbidity and mortality. We report 2 cases of disseminated nocardiosis with pulmonary and central nervous system involvement in kidney transplant recipients. Nocardiosis should be suspected in immunocompromised patients with fever and lung mass, although atypical presentations involving almost any organ can be seen. Solid organ transplant recipients are at greatest risk for Nocardia infection within the first 1 to 2 years after transplantation. However, the patients presented here developed disseminated nocardiosis several years after transplantation, which has important implications. Nocardiosis is treated with 2 to 6 weeks of empiric induction antibiotics, followed by 6 to 12 months of maintenance antibiotics based on antimicrobial susceptibility testing. |
| first_indexed | 2024-04-11T07:49:44Z |
| format | Article |
| id | doaj.art-b7ac54c88b7d4b54a19ea4284d16baf3 |
| institution | Directory Open Access Journal |
| issn | 2590-0595 |
| language | English |
| last_indexed | 2024-04-11T07:49:44Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj.art-b7ac54c88b7d4b54a19ea4284d16baf32022-12-22T04:36:08ZengElsevierKidney Medicine2590-05952022-12-01412100551Disseminated Nocardiosis in Kidney Transplant Recipients: A Report of 2 CasesAlissar El Chediak0Jefferson L. Triozzi1Heidi Schaefer2Saed Shawar3Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TennesseeDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TennesseeDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TennesseeDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Address for Correspondence: Saed H. Shawar, MD, Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37232.Nocardiosis is a rare, life-threatening opportunistic infection caused by bacteria in the environment that predominantly affects immunocompromised patients. Nocardiosis most commonly involves the lungs but can disseminate to other organs. Disseminated nocardiosis, defined as Nocardia infection involving 2 or more organ systems, requires early detection and treatment because of high morbidity and mortality. We report 2 cases of disseminated nocardiosis with pulmonary and central nervous system involvement in kidney transplant recipients. Nocardiosis should be suspected in immunocompromised patients with fever and lung mass, although atypical presentations involving almost any organ can be seen. Solid organ transplant recipients are at greatest risk for Nocardia infection within the first 1 to 2 years after transplantation. However, the patients presented here developed disseminated nocardiosis several years after transplantation, which has important implications. Nocardiosis is treated with 2 to 6 weeks of empiric induction antibiotics, followed by 6 to 12 months of maintenance antibiotics based on antimicrobial susceptibility testing.http://www.sciencedirect.com/science/article/pii/S2590059522001777Disseminated infectionimmunocompromisedkidney transplantopportunistic infection |
| spellingShingle | Alissar El Chediak Jefferson L. Triozzi Heidi Schaefer Saed Shawar Disseminated Nocardiosis in Kidney Transplant Recipients: A Report of 2 Cases Kidney Medicine Disseminated infection immunocompromised kidney transplant opportunistic infection |
| title | Disseminated Nocardiosis in Kidney Transplant Recipients: A Report of 2 Cases |
| title_full | Disseminated Nocardiosis in Kidney Transplant Recipients: A Report of 2 Cases |
| title_fullStr | Disseminated Nocardiosis in Kidney Transplant Recipients: A Report of 2 Cases |
| title_full_unstemmed | Disseminated Nocardiosis in Kidney Transplant Recipients: A Report of 2 Cases |
| title_short | Disseminated Nocardiosis in Kidney Transplant Recipients: A Report of 2 Cases |
| title_sort | disseminated nocardiosis in kidney transplant recipients a report of 2 cases |
| topic | Disseminated infection immunocompromised kidney transplant opportunistic infection |
| url | http://www.sciencedirect.com/science/article/pii/S2590059522001777 |
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