The Role of Chlamydia trachomatis IgG Antibody Testing in Predicting Tubal Factor Infertility in Northern Iran
Background The purpose of this study was to investigate the role of Chlamydia serology as a screening test for tubal infertility and to compare the results with hysterosalpingography (HSG) and laparoscopic findings. Materials and methods This was a cross-sectional study undertaken on 110 infertile...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Royan Institute (ACECR), Tehran
2009-11-01
|
| Series: | International Journal of Fertility and Sterility |
| Subjects: | |
| Online Access: | http://www.ijfs.ir/article_45787_86dd70aebb4b41dcffa788a9cbb816a5.pdf |
| _version_ | 1818452724031684608 |
|---|---|
| author | Sepideh Peivandi Narges Moslemizadeh Saeideh Gharajeh Abolghasem Ajami |
| author_facet | Sepideh Peivandi Narges Moslemizadeh Saeideh Gharajeh Abolghasem Ajami |
| author_sort | Sepideh Peivandi |
| collection | DOAJ |
| description | Background
The purpose of this study was to investigate the role of Chlamydia serology as a screening test for tubal infertility and to compare the results with hysterosalpingography (HSG) and laparoscopic findings.
Materials and methods
This was a cross-sectional study undertaken on 110 infertile women treated in the IVF Ward, at Emam Khomeini Hospital, Sari, Iran who underwent laparoscopy and HSG as part of their infertility workup. Prior to laparoscopy, 5 ml of venous blood was drawn for measurement of serum Chlamydia IgG antibody titer (CAT). Patients’ tubal status and pelvic findings were compared with CAT, as measured by microimmunofluorescence.
Results
Tuboperitoneal abnormalities were seen in 81.4% of seropositive patients versus 13.2% of women who were seronegative. In women with tubal damage, the numbers of positive CATs (≥1:32) were significantly more than in those who had a normal pelvis (66.6% vs. 6.5%, p<0.001). CAT levels were higher in patients who had bilateral hydrosalpinges, bilateral tubal occlusion and pelvic adhesions (severe damage), than those with tubal distortion and unilateral occlusion (mild damage) (p<0.05). The positive likelihood ratio for C. trachomatis antibody testing was 10.28 as compared with HSG, which had a positive likelihood ratio of 3.03.
Conclusion
The results of this study revealed that C. trachomatis serology is an inexpensive and non-invasive test for tubal factor infertility screening. |
| first_indexed | 2024-12-14T21:27:38Z |
| format | Article |
| id | doaj.art-b7ad408164784be8a90b5dad7c9c7b44 |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-12-14T21:27:38Z |
| publishDate | 2009-11-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-b7ad408164784be8a90b5dad7c9c7b442022-12-21T22:46:46ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782009-11-013314314810.22074/ijfs.2009.4578745787The Role of Chlamydia trachomatis IgG Antibody Testing in Predicting Tubal Factor Infertility in Northern IranSepideh Peivandi0Narges Moslemizadeh1Saeideh Gharajeh2Abolghasem Ajami3Obstetrics and Gynecology Department, Infertility Ward, Emam Khomeini Hospital, Mazandaran University of Medical Science, Sari, IranObstetrics and Gynecology Department, Infertility Ward, Emam Khomeini Hospital, Mazandaran University of Medical Science, Sari, IranObstetrics and Gynecology Department, Infertility Ward, Emam Khomeini Hospital, Mazandaran University of Medical Science, Sari, IranObstetrics and Gynecology Department, Infertility Ward, Emam Khomeini Hospital, Mazandaran University of Medical Science, Sari, IranBackground The purpose of this study was to investigate the role of Chlamydia serology as a screening test for tubal infertility and to compare the results with hysterosalpingography (HSG) and laparoscopic findings. Materials and methods This was a cross-sectional study undertaken on 110 infertile women treated in the IVF Ward, at Emam Khomeini Hospital, Sari, Iran who underwent laparoscopy and HSG as part of their infertility workup. Prior to laparoscopy, 5 ml of venous blood was drawn for measurement of serum Chlamydia IgG antibody titer (CAT). Patients’ tubal status and pelvic findings were compared with CAT, as measured by microimmunofluorescence. Results Tuboperitoneal abnormalities were seen in 81.4% of seropositive patients versus 13.2% of women who were seronegative. In women with tubal damage, the numbers of positive CATs (≥1:32) were significantly more than in those who had a normal pelvis (66.6% vs. 6.5%, p<0.001). CAT levels were higher in patients who had bilateral hydrosalpinges, bilateral tubal occlusion and pelvic adhesions (severe damage), than those with tubal distortion and unilateral occlusion (mild damage) (p<0.05). The positive likelihood ratio for C. trachomatis antibody testing was 10.28 as compared with HSG, which had a positive likelihood ratio of 3.03. Conclusion The results of this study revealed that C. trachomatis serology is an inexpensive and non-invasive test for tubal factor infertility screening.http://www.ijfs.ir/article_45787_86dd70aebb4b41dcffa788a9cbb816a5.pdfinfertilitychlamydiaantibodylaparoscopyhysterosalpingography |
| spellingShingle | Sepideh Peivandi Narges Moslemizadeh Saeideh Gharajeh Abolghasem Ajami The Role of Chlamydia trachomatis IgG Antibody Testing in Predicting Tubal Factor Infertility in Northern Iran International Journal of Fertility and Sterility infertility chlamydia antibody laparoscopy hysterosalpingography |
| title | The Role of Chlamydia trachomatis IgG Antibody Testing in Predicting Tubal Factor Infertility in Northern Iran |
| title_full | The Role of Chlamydia trachomatis IgG Antibody Testing in Predicting Tubal Factor Infertility in Northern Iran |
| title_fullStr | The Role of Chlamydia trachomatis IgG Antibody Testing in Predicting Tubal Factor Infertility in Northern Iran |
| title_full_unstemmed | The Role of Chlamydia trachomatis IgG Antibody Testing in Predicting Tubal Factor Infertility in Northern Iran |
| title_short | The Role of Chlamydia trachomatis IgG Antibody Testing in Predicting Tubal Factor Infertility in Northern Iran |
| title_sort | role of chlamydia trachomatis igg antibody testing in predicting tubal factor infertility in northern iran |
| topic | infertility chlamydia antibody laparoscopy hysterosalpingography |
| url | http://www.ijfs.ir/article_45787_86dd70aebb4b41dcffa788a9cbb816a5.pdf |
| work_keys_str_mv | AT sepidehpeivandi theroleofchlamydiatrachomatisiggantibodytestinginpredictingtubalfactorinfertilityinnortherniran AT nargesmoslemizadeh theroleofchlamydiatrachomatisiggantibodytestinginpredictingtubalfactorinfertilityinnortherniran AT saeidehgharajeh theroleofchlamydiatrachomatisiggantibodytestinginpredictingtubalfactorinfertilityinnortherniran AT abolghasemajami theroleofchlamydiatrachomatisiggantibodytestinginpredictingtubalfactorinfertilityinnortherniran AT sepidehpeivandi roleofchlamydiatrachomatisiggantibodytestinginpredictingtubalfactorinfertilityinnortherniran AT nargesmoslemizadeh roleofchlamydiatrachomatisiggantibodytestinginpredictingtubalfactorinfertilityinnortherniran AT saeidehgharajeh roleofchlamydiatrachomatisiggantibodytestinginpredictingtubalfactorinfertilityinnortherniran AT abolghasemajami roleofchlamydiatrachomatisiggantibodytestinginpredictingtubalfactorinfertilityinnortherniran |