Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?

Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?

Animal model studies and first clinical trials have demonstrated the safety and efficacy of the mesenchymal stem cells’ (MSCs) transplantation in stroke. Intra-arterial (IA) administration looks especially promising, since it provides targeted cell delivery to the ischemic brain, is highly effective...

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Bibliographic Details
Main Authors: Konstantin N. Yarygin, Daria D. Namestnikova, Kirill K. Sukhinich, Ilya L. Gubskiy, Alexander G. Majouga, Irina V. Kholodenko
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
mesenchymal stem cells
cell therapy
stroke
blood–brain barrier
neurovascular unit
stroke models
Online Access:https://www.mdpi.com/2073-4409/10/11/2997

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