Heterogeneity in the Metastatic Microenvironment: JunB-Expressing Microglia Cells as Potential Drivers of Melanoma Brain Metastasis Progression

Heterogeneity in the Metastatic Microenvironment: JunB-Expressing Microglia Cells as Potential Drivers of Melanoma Brain Metastasis Progression

Reciprocal signaling between melanoma brain metastatic (MBM) cells and microglia reprograms the phenotype of both interaction partners, including upregulation of the transcription factor JunB in microglia. Here, we aimed to elucidate the impact of microglial JunB upregulation on MBM progression. For...

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Bibliographic Details
Main Authors: Orit Adir, Orit Sagi-Assif, Tsipi Meshel, Shlomit Ben-Menachem, Metsada Pasmanik-Chor, Dave S. B. Hoon, Isaac P. Witz, Sivan Izraely
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
melanoma
brain metastasis
microglia
tumor microenvironment
immune microenvironment
JunB
Online Access:https://www.mdpi.com/2072-6694/15/20/4979

Internet

https://www.mdpi.com/2072-6694/15/20/4979

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