Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution
Many RNA systems possess highly ordered 3-D structures that are essential to their function. Here the authors demonstrate that the long non-coding RNA Braveheart possesses a flexible but defined 3-D structure which is remodeled upon binding the protein CNBP.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13942-4 |
| _version_ | 1828976722333138944 |
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| author | Doo Nam Kim Bernhard C. Thiel Tyler Mrozowich Scott P. Hennelly Ivo L. Hofacker Trushar R. Patel Karissa Y. Sanbonmatsu |
| author_facet | Doo Nam Kim Bernhard C. Thiel Tyler Mrozowich Scott P. Hennelly Ivo L. Hofacker Trushar R. Patel Karissa Y. Sanbonmatsu |
| author_sort | Doo Nam Kim |
| collection | DOAJ |
| description | Many RNA systems possess highly ordered 3-D structures that are essential to their function. Here the authors demonstrate that the long non-coding RNA Braveheart possesses a flexible but defined 3-D structure which is remodeled upon binding the protein CNBP. |
| first_indexed | 2024-12-14T14:42:59Z |
| format | Article |
| id | doaj.art-b7b190fd83ef4f3290654e561d22e685 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:42:59Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b7b190fd83ef4f3290654e561d22e6852022-12-21T22:57:21ZengNature PortfolioNature Communications2041-17232020-01-0111111310.1038/s41467-019-13942-4Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solutionDoo Nam Kim0Bernhard C. Thiel1Tyler Mrozowich2Scott P. Hennelly3Ivo L. Hofacker4Trushar R. Patel5Karissa Y. Sanbonmatsu6Theoretical Biology and Biophysics Group, Los Alamos National LaboratoryDepartment of Theoretical Chemistry, University of ViennaAlberta RNA Research & Training Institute, Department of Chemistry and Biochemistry, University of LethbridgeTheoretical Biology and Biophysics Group, Los Alamos National LaboratoryDepartment of Theoretical Chemistry, University of ViennaAlberta RNA Research & Training Institute, Department of Chemistry and Biochemistry, University of LethbridgeTheoretical Biology and Biophysics Group, Los Alamos National LaboratoryMany RNA systems possess highly ordered 3-D structures that are essential to their function. Here the authors demonstrate that the long non-coding RNA Braveheart possesses a flexible but defined 3-D structure which is remodeled upon binding the protein CNBP.https://doi.org/10.1038/s41467-019-13942-4 |
| spellingShingle | Doo Nam Kim Bernhard C. Thiel Tyler Mrozowich Scott P. Hennelly Ivo L. Hofacker Trushar R. Patel Karissa Y. Sanbonmatsu Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution Nature Communications |
| title | Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution |
| title_full | Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution |
| title_fullStr | Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution |
| title_full_unstemmed | Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution |
| title_short | Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution |
| title_sort | zinc finger protein cnbp alters the 3 d structure of lncrna braveheart in solution |
| url | https://doi.org/10.1038/s41467-019-13942-4 |
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