Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study
Genetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270...
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MDPI AG
2022-09-01
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| Online Access: | https://www.mdpi.com/2227-9067/9/10/1421 |
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| author | Takeshi Ota Jun Mori Yasuhiro Kawabe Hidechika Morimoto Shota Fukuhara Kazuki Kodo Satoru Sugimoto Kitaro Kosaka Hisakazu Nakajima Hajime Hosoi |
| author_facet | Takeshi Ota Jun Mori Yasuhiro Kawabe Hidechika Morimoto Shota Fukuhara Kazuki Kodo Satoru Sugimoto Kitaro Kosaka Hisakazu Nakajima Hajime Hosoi |
| author_sort | Takeshi Ota |
| collection | DOAJ |
| description | Genetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270 non-obese and 86 obese children. All participants underwent genotyping for type 2 deiodinase (DIO2) Thr92Ala (rs225014). The prevalence of the homozygous Ala/Ala allele of the DIO2 gene in the obese group was 15.1% versus 6.3% in the non-obese group, resulting in an odds ratio (OR) of 3.393 (<i>p</i> = 0.003). The results of this study indicate that the homozygous Ala/Ala allele of the DIO2 gene is associated with an increased risk of pediatric obesity and suggest that pediatric obesity might be suitable for assessing the association with gene polymorphisms related to BAT, especially DIO2 Thr92Ala. |
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| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T20:28:26Z |
| publishDate | 2022-09-01 |
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| series | Children |
| spelling | doaj.art-b7b700ccb5ec4fbea2105c8c90c4ff0b2023-11-23T23:30:42ZengMDPI AGChildren2227-90672022-09-01910142110.3390/children9101421Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control StudyTakeshi Ota0Jun Mori1Yasuhiro Kawabe2Hidechika Morimoto3Shota Fukuhara4Kazuki Kodo5Satoru Sugimoto6Kitaro Kosaka7Hisakazu Nakajima8Hajime Hosoi9Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanGenetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270 non-obese and 86 obese children. All participants underwent genotyping for type 2 deiodinase (DIO2) Thr92Ala (rs225014). The prevalence of the homozygous Ala/Ala allele of the DIO2 gene in the obese group was 15.1% versus 6.3% in the non-obese group, resulting in an odds ratio (OR) of 3.393 (<i>p</i> = 0.003). The results of this study indicate that the homozygous Ala/Ala allele of the DIO2 gene is associated with an increased risk of pediatric obesity and suggest that pediatric obesity might be suitable for assessing the association with gene polymorphisms related to BAT, especially DIO2 Thr92Ala.https://www.mdpi.com/2227-9067/9/10/1421pediatric obesitybrown adipose tissuetype 2 deiodinaseuncoupling protein 1β3 adrenergic receptor |
| spellingShingle | Takeshi Ota Jun Mori Yasuhiro Kawabe Hidechika Morimoto Shota Fukuhara Kazuki Kodo Satoru Sugimoto Kitaro Kosaka Hisakazu Nakajima Hajime Hosoi Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study Children pediatric obesity brown adipose tissue type 2 deiodinase uncoupling protein 1 β3 adrenergic receptor |
| title | Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study |
| title_full | Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study |
| title_fullStr | Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study |
| title_full_unstemmed | Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study |
| title_short | Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study |
| title_sort | association of type 2 deiodinase thr92ala polymorphism with pediatric obesity in japanese children a case control study |
| topic | pediatric obesity brown adipose tissue type 2 deiodinase uncoupling protein 1 β3 adrenergic receptor |
| url | https://www.mdpi.com/2227-9067/9/10/1421 |
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