Circulating Blood-Based Biomarkers in Pulmonary Hypertension
Pulmonary hypertension (PH) is a serious hemodynamic condition, characterized by increased pulmonary vascular resistance (PVR), leading to right heart failure (HF) and death when not properly treated. The prognosis of PH depends on etiology, hemodynamic and biochemical parameters, as well as on resp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/2/383 |
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| author | Marta Banaszkiewicz Aleksandra Gąsecka Szymon Darocha Michał Florczyk Arkadiusz Pietrasik Piotr Kędzierski Michał Piłka Adam Torbicki Marcin Kurzyna |
| author_facet | Marta Banaszkiewicz Aleksandra Gąsecka Szymon Darocha Michał Florczyk Arkadiusz Pietrasik Piotr Kędzierski Michał Piłka Adam Torbicki Marcin Kurzyna |
| author_sort | Marta Banaszkiewicz |
| collection | DOAJ |
| description | Pulmonary hypertension (PH) is a serious hemodynamic condition, characterized by increased pulmonary vascular resistance (PVR), leading to right heart failure (HF) and death when not properly treated. The prognosis of PH depends on etiology, hemodynamic and biochemical parameters, as well as on response to specific treatment. Biomarkers appear to be useful noninvasive tools, providing information about the disease severity, treatment response, and prognosis. However, given the complexity of PH, it is impossible for a single biomarker to be adequate for the broad assessment of patients with different types of PH. The search for novel emerging biomarkers is still ongoing, resulting in a few potential biomarkers mirroring numerous pathophysiological courses. In this review, markers related to HF, myocardial remodeling, inflammation, hypoxia and tissue damage, and endothelial and pulmonary smooth muscle cell dysfunction are discussed in terms of diagnosis and prognosis. Extracellular vesicles and other markers with complex backgrounds are also reviewed. In conclusion, although many promising biomarkers have been identified and studied in recent years, there are still insufficient data on the application of multimarker strategies for monitoring and risk stratification in PH patients. |
| first_indexed | 2024-03-10T01:13:27Z |
| format | Article |
| id | doaj.art-b7ba1dc3180b456aa66b081fa17bfa31 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:13:27Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b7ba1dc3180b456aa66b081fa17bfa312023-11-23T14:13:09ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111238310.3390/jcm11020383Circulating Blood-Based Biomarkers in Pulmonary HypertensionMarta Banaszkiewicz0Aleksandra Gąsecka1Szymon Darocha2Michał Florczyk3Arkadiusz Pietrasik4Piotr Kędzierski5Michał Piłka6Adam Torbicki7Marcin Kurzyna8Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, 05-400 Warsaw, Poland1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, 05-400 Warsaw, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, 05-400 Warsaw, Poland1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, 05-400 Warsaw, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, 05-400 Warsaw, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, 05-400 Warsaw, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, 05-400 Warsaw, PolandPulmonary hypertension (PH) is a serious hemodynamic condition, characterized by increased pulmonary vascular resistance (PVR), leading to right heart failure (HF) and death when not properly treated. The prognosis of PH depends on etiology, hemodynamic and biochemical parameters, as well as on response to specific treatment. Biomarkers appear to be useful noninvasive tools, providing information about the disease severity, treatment response, and prognosis. However, given the complexity of PH, it is impossible for a single biomarker to be adequate for the broad assessment of patients with different types of PH. The search for novel emerging biomarkers is still ongoing, resulting in a few potential biomarkers mirroring numerous pathophysiological courses. In this review, markers related to HF, myocardial remodeling, inflammation, hypoxia and tissue damage, and endothelial and pulmonary smooth muscle cell dysfunction are discussed in terms of diagnosis and prognosis. Extracellular vesicles and other markers with complex backgrounds are also reviewed. In conclusion, although many promising biomarkers have been identified and studied in recent years, there are still insufficient data on the application of multimarker strategies for monitoring and risk stratification in PH patients.https://www.mdpi.com/2077-0383/11/2/383pulmonary hypertensionchronic thromboembolic pulmonary hypertensionpulmonary arterial hypertensionbiomarkersright heart failure |
| spellingShingle | Marta Banaszkiewicz Aleksandra Gąsecka Szymon Darocha Michał Florczyk Arkadiusz Pietrasik Piotr Kędzierski Michał Piłka Adam Torbicki Marcin Kurzyna Circulating Blood-Based Biomarkers in Pulmonary Hypertension Journal of Clinical Medicine pulmonary hypertension chronic thromboembolic pulmonary hypertension pulmonary arterial hypertension biomarkers right heart failure |
| title | Circulating Blood-Based Biomarkers in Pulmonary Hypertension |
| title_full | Circulating Blood-Based Biomarkers in Pulmonary Hypertension |
| title_fullStr | Circulating Blood-Based Biomarkers in Pulmonary Hypertension |
| title_full_unstemmed | Circulating Blood-Based Biomarkers in Pulmonary Hypertension |
| title_short | Circulating Blood-Based Biomarkers in Pulmonary Hypertension |
| title_sort | circulating blood based biomarkers in pulmonary hypertension |
| topic | pulmonary hypertension chronic thromboembolic pulmonary hypertension pulmonary arterial hypertension biomarkers right heart failure |
| url | https://www.mdpi.com/2077-0383/11/2/383 |
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