USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities
Ubiquitin specific protease 5 (USP5) is a vital deubiquitinating enzyme that regulates various physiological functions by removing ubiquitin chains from target proteins. This review provides an overview of the structural and functional characteristics of USP5. Additionally, we discuss the role of US...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Molecular and Cellular Probes |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0890850823000531 |
| _version_ | 1797296228393811968 |
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| author | Si-Ting Gao Xin Xin Zhuo-yuan Wang Yi-yang Hu Qin Feng |
| author_facet | Si-Ting Gao Xin Xin Zhuo-yuan Wang Yi-yang Hu Qin Feng |
| author_sort | Si-Ting Gao |
| collection | DOAJ |
| description | Ubiquitin specific protease 5 (USP5) is a vital deubiquitinating enzyme that regulates various physiological functions by removing ubiquitin chains from target proteins. This review provides an overview of the structural and functional characteristics of USP5. Additionally, we discuss the role of USP5 in regulating diverse cellular processes, including cell proliferation, apoptosis, DNA double-strand damage, methylation, heat stress, and protein quality control, by targeting different substrates. Furthermore, we describe the involvement of USP5 in several pathological conditions such as tumors, pathological pain, developmental abnormalities, inflammatory diseases, and virus infection. Finally, we introduce newly developed inhibitors of USP5. In conclusion, investigating the novel functions and substrates of USP5, elucidating the underlying mechanisms of USP5-substrate interactions, intensifying the development of inhibitors, and exploring the upstream regulatory mechanisms of USP5 in detail can provide a new theoretical basis for the treatment of various diseases, including cancer, which is a promising research direction with considerable potential. Overall, USP5 plays a critical role in regulating various physiological and pathological processes, and investigating its novel functions and regulatory mechanisms may have significant implications for the development of therapeutic strategies for cancer and other diseases. |
| first_indexed | 2024-03-07T22:01:25Z |
| format | Article |
| id | doaj.art-b7bd8ed6ea474834a94ab1b47c989c11 |
| institution | Directory Open Access Journal |
| issn | 0890-8508 |
| language | English |
| last_indexed | 2024-03-07T22:01:25Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular and Cellular Probes |
| spelling | doaj.art-b7bd8ed6ea474834a94ab1b47c989c112024-02-24T04:54:25ZengElsevierMolecular and Cellular Probes0890-85082024-02-0173101944USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunitiesSi-Ting Gao0Xin Xin1Zhuo-yuan Wang2Yi-yang Hu3Qin Feng4Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaKey Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine, Ministry of Education, Shanghai, ChinaInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine, Ministry of Education, Shanghai, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China; Corresponding author. Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine, Ministry of Education, Shanghai, China; Central Laboratory, ShuGuang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China; Corresponding author. Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.Ubiquitin specific protease 5 (USP5) is a vital deubiquitinating enzyme that regulates various physiological functions by removing ubiquitin chains from target proteins. This review provides an overview of the structural and functional characteristics of USP5. Additionally, we discuss the role of USP5 in regulating diverse cellular processes, including cell proliferation, apoptosis, DNA double-strand damage, methylation, heat stress, and protein quality control, by targeting different substrates. Furthermore, we describe the involvement of USP5 in several pathological conditions such as tumors, pathological pain, developmental abnormalities, inflammatory diseases, and virus infection. Finally, we introduce newly developed inhibitors of USP5. In conclusion, investigating the novel functions and substrates of USP5, elucidating the underlying mechanisms of USP5-substrate interactions, intensifying the development of inhibitors, and exploring the upstream regulatory mechanisms of USP5 in detail can provide a new theoretical basis for the treatment of various diseases, including cancer, which is a promising research direction with considerable potential. Overall, USP5 plays a critical role in regulating various physiological and pathological processes, and investigating its novel functions and regulatory mechanisms may have significant implications for the development of therapeutic strategies for cancer and other diseases.http://www.sciencedirect.com/science/article/pii/S0890850823000531USP5Deubiquitinating enzymesCancerInflammation |
| spellingShingle | Si-Ting Gao Xin Xin Zhuo-yuan Wang Yi-yang Hu Qin Feng USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities Molecular and Cellular Probes USP5 Deubiquitinating enzymes Cancer Inflammation |
| title | USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities |
| title_full | USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities |
| title_fullStr | USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities |
| title_full_unstemmed | USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities |
| title_short | USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities |
| title_sort | usp5 comprehensive insights into structure function biological and disease related implications and emerging therapeutic opportunities |
| topic | USP5 Deubiquitinating enzymes Cancer Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S0890850823000531 |
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