Correlation Between STK11 Gene Mutation and Immunotherapy of Non-small Cell Lung Cancer
Lung cancer is one of the most common malignant tumors. Globally, the incidence and mortality of lung cancer are very high and on the rise. In recent years, immune checkpoint inhibitors (ICIs) have a significant survival advantage in treating advanced NSCLC. However, for NSCLC patients with positive...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2022-08-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.1133 |
| _version_ | 1828345724228599808 |
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| author | XIA Siyu ZHAO Zitong LI Li |
| author_facet | XIA Siyu ZHAO Zitong LI Li |
| author_sort | XIA Siyu |
| collection | DOAJ |
| description | Lung cancer is one of the most common malignant tumors. Globally, the incidence and mortality of lung cancer are very high and on the rise. In recent years, immune checkpoint inhibitors (ICIs) have a significant survival advantage in treating advanced NSCLC. However, for NSCLC patients with positive driver genes, ICIs are not effective. But some tumor suppressor genes have varying degrees of impact on immunotherapy through mutations or deletions. Among them, serine/threonine kinase 11 (STK11) gene mutations are closely related to PD-1/PD-L1 ICIs. Studies have found that STK11 mutations are related to reduced immune cell infiltration, low PD-L1 expression and poor response to PD-L1 inhibition. This article reviews the research progress of the correlation between STK11 gene mutation and immunotherapy on NSCLC. |
| first_indexed | 2024-04-14T00:15:25Z |
| format | Article |
| id | doaj.art-b7bee8026ac746808c55fd7c8ddaca4c |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-04-14T00:15:25Z |
| publishDate | 2022-08-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-b7bee8026ac746808c55fd7c8ddaca4c2022-12-22T02:23:08ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782022-08-0149885085410.3971/j.issn.1000-8578.2022.21.11338578.2022.21.1133Correlation Between STK11 Gene Mutation and Immunotherapy of Non-small Cell Lung CancerXIA Siyu0ZHAO Zitong1LI Li2Medical Oncology Second Ward, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaMedical Oncology Second Ward, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaMedical Oncology Second Ward, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaLung cancer is one of the most common malignant tumors. Globally, the incidence and mortality of lung cancer are very high and on the rise. In recent years, immune checkpoint inhibitors (ICIs) have a significant survival advantage in treating advanced NSCLC. However, for NSCLC patients with positive driver genes, ICIs are not effective. But some tumor suppressor genes have varying degrees of impact on immunotherapy through mutations or deletions. Among them, serine/threonine kinase 11 (STK11) gene mutations are closely related to PD-1/PD-L1 ICIs. Studies have found that STK11 mutations are related to reduced immune cell infiltration, low PD-L1 expression and poor response to PD-L1 inhibition. This article reviews the research progress of the correlation between STK11 gene mutation and immunotherapy on NSCLC.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.1133stk11icisnsclcgene mutationimmunotherapy |
| spellingShingle | XIA Siyu ZHAO Zitong LI Li Correlation Between STK11 Gene Mutation and Immunotherapy of Non-small Cell Lung Cancer Zhongliu Fangzhi Yanjiu stk11 icis nsclc gene mutation immunotherapy |
| title | Correlation Between STK11 Gene Mutation and Immunotherapy of Non-small Cell Lung Cancer |
| title_full | Correlation Between STK11 Gene Mutation and Immunotherapy of Non-small Cell Lung Cancer |
| title_fullStr | Correlation Between STK11 Gene Mutation and Immunotherapy of Non-small Cell Lung Cancer |
| title_full_unstemmed | Correlation Between STK11 Gene Mutation and Immunotherapy of Non-small Cell Lung Cancer |
| title_short | Correlation Between STK11 Gene Mutation and Immunotherapy of Non-small Cell Lung Cancer |
| title_sort | correlation between stk11 gene mutation and immunotherapy of non small cell lung cancer |
| topic | stk11 icis nsclc gene mutation immunotherapy |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.1133 |
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