The Bacterial Gut Microbiota of Schoolchildren from High and Low Socioeconomic Status: A Study in an Urban Area of Makassar, Indonesia
To understand the relationship between the gut microbiota and the health profile of Indonesians, it is important to elucidate the characteristics of the bacterial communities that prevail in this population. To this end, we profiled the faecal bacterial community of 140 Indonesian schoolchildren in...
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MDPI AG
2020-06-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/6/961 |
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| author | Aldian I. Amaruddin Firdaus Hamid Jan Pieter R. Koopman Munawir Muhammad Eric A.T. Brienen Lisette van Lieshout Anoecim R. Geelen Sitti Wahyuni Ed J. Kuijper Erliyani Sartono Maria Yazdanbakhsh Romy D. Zwittink |
| author_facet | Aldian I. Amaruddin Firdaus Hamid Jan Pieter R. Koopman Munawir Muhammad Eric A.T. Brienen Lisette van Lieshout Anoecim R. Geelen Sitti Wahyuni Ed J. Kuijper Erliyani Sartono Maria Yazdanbakhsh Romy D. Zwittink |
| author_sort | Aldian I. Amaruddin |
| collection | DOAJ |
| description | To understand the relationship between the gut microbiota and the health profile of Indonesians, it is important to elucidate the characteristics of the bacterial communities that prevail in this population. To this end, we profiled the faecal bacterial community of 140 Indonesian schoolchildren in urban Makassar. The core microbiota of Indonesian schoolchildren consisted of <i>Bifidobacterium</i>, <i>Collinsella</i>, and multiple members of the <i>Lachnospiraceae</i> and <i>Ruminicoccaceae</i> families, but the relative abundance of these taxa varied greatly among children. Socioeconomic status (SES) was the main driver for differences in microbiota composition. Multiple bacterial genera were differentially abundant between high and low SES children, including <i>Bifidobacterium, Lactobacillus, Prevotella</i>, and <i>Escherichia-Shigella</i>. In addition, the microbiota of high SES children was less diverse and strongly associated with body mass index (BMI). In low SES children, helminth infection was prevalent and positively associated with <i>Olsenella, Enterohabdus,</i> <i>Lactobacillus</i>, and <i>Mogibacterium</i> abundance, while negatively associated with relative abundance of <i>Prevotella</i>. Protozoa infection was also prevalent, and positively associated with <i>Rikenellaceae,</i> while it was negatively associated with the relative abundance of <i>Romboutsia</i> and <i>Prevotella</i>. In conclusion, Indonesian schoolchildren living in urban Makassar share a core microbiota, but their microbiota varies in diversity and relative abundance of specific bacterial taxa depending on socioeconomic status, nutritional status, and intestinal parasites infection. |
| first_indexed | 2024-03-10T18:52:38Z |
| format | Article |
| id | doaj.art-b7bf78f944404c1fa48e9b1c58ab3ea4 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T18:52:38Z |
| publishDate | 2020-06-01 |
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| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-b7bf78f944404c1fa48e9b1c58ab3ea42023-11-20T05:04:26ZengMDPI AGMicroorganisms2076-26072020-06-018696110.3390/microorganisms8060961The Bacterial Gut Microbiota of Schoolchildren from High and Low Socioeconomic Status: A Study in an Urban Area of Makassar, IndonesiaAldian I. Amaruddin0Firdaus Hamid1Jan Pieter R. Koopman2Munawir Muhammad3Eric A.T. Brienen4Lisette van Lieshout5Anoecim R. Geelen6Sitti Wahyuni7Ed J. Kuijper8Erliyani Sartono9Maria Yazdanbakhsh10Romy D. Zwittink11Department of Parasitology, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsDepartment of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar 90245, IndonesiaDepartment of Parasitology, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsDepartment of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar 90245, IndonesiaDepartment of Parasitology, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsDepartment of Parasitology, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsExperimental Bacteriology, Department of Medical Microbiology, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsDepartment of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar 90245, IndonesiaExperimental Bacteriology, Department of Medical Microbiology, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsDepartment of Parasitology, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsDepartment of Parasitology, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsExperimental Bacteriology, Department of Medical Microbiology, Leiden University Medical Center, 2333ZA Leiden, The NetherlandsTo understand the relationship between the gut microbiota and the health profile of Indonesians, it is important to elucidate the characteristics of the bacterial communities that prevail in this population. To this end, we profiled the faecal bacterial community of 140 Indonesian schoolchildren in urban Makassar. The core microbiota of Indonesian schoolchildren consisted of <i>Bifidobacterium</i>, <i>Collinsella</i>, and multiple members of the <i>Lachnospiraceae</i> and <i>Ruminicoccaceae</i> families, but the relative abundance of these taxa varied greatly among children. Socioeconomic status (SES) was the main driver for differences in microbiota composition. Multiple bacterial genera were differentially abundant between high and low SES children, including <i>Bifidobacterium, Lactobacillus, Prevotella</i>, and <i>Escherichia-Shigella</i>. In addition, the microbiota of high SES children was less diverse and strongly associated with body mass index (BMI). In low SES children, helminth infection was prevalent and positively associated with <i>Olsenella, Enterohabdus,</i> <i>Lactobacillus</i>, and <i>Mogibacterium</i> abundance, while negatively associated with relative abundance of <i>Prevotella</i>. Protozoa infection was also prevalent, and positively associated with <i>Rikenellaceae,</i> while it was negatively associated with the relative abundance of <i>Romboutsia</i> and <i>Prevotella</i>. In conclusion, Indonesian schoolchildren living in urban Makassar share a core microbiota, but their microbiota varies in diversity and relative abundance of specific bacterial taxa depending on socioeconomic status, nutritional status, and intestinal parasites infection.https://www.mdpi.com/2076-2607/8/6/961gut microbiotasocioeconomic statusintestinal parasitesnutritional statusschoolchildren |
| spellingShingle | Aldian I. Amaruddin Firdaus Hamid Jan Pieter R. Koopman Munawir Muhammad Eric A.T. Brienen Lisette van Lieshout Anoecim R. Geelen Sitti Wahyuni Ed J. Kuijper Erliyani Sartono Maria Yazdanbakhsh Romy D. Zwittink The Bacterial Gut Microbiota of Schoolchildren from High and Low Socioeconomic Status: A Study in an Urban Area of Makassar, Indonesia Microorganisms gut microbiota socioeconomic status intestinal parasites nutritional status schoolchildren |
| title | The Bacterial Gut Microbiota of Schoolchildren from High and Low Socioeconomic Status: A Study in an Urban Area of Makassar, Indonesia |
| title_full | The Bacterial Gut Microbiota of Schoolchildren from High and Low Socioeconomic Status: A Study in an Urban Area of Makassar, Indonesia |
| title_fullStr | The Bacterial Gut Microbiota of Schoolchildren from High and Low Socioeconomic Status: A Study in an Urban Area of Makassar, Indonesia |
| title_full_unstemmed | The Bacterial Gut Microbiota of Schoolchildren from High and Low Socioeconomic Status: A Study in an Urban Area of Makassar, Indonesia |
| title_short | The Bacterial Gut Microbiota of Schoolchildren from High and Low Socioeconomic Status: A Study in an Urban Area of Makassar, Indonesia |
| title_sort | bacterial gut microbiota of schoolchildren from high and low socioeconomic status a study in an urban area of makassar indonesia |
| topic | gut microbiota socioeconomic status intestinal parasites nutritional status schoolchildren |
| url | https://www.mdpi.com/2076-2607/8/6/961 |
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