The leukotriene B₄/BLT₁ axis is a key determinant in susceptibility and resistance to histoplasmosis.

The leukotriene B₄/BLT₁ axis is a key determinant in susceptibility and resistance to histoplasmosis.

The bioactive lipid mediator leukotriene B4 (LTB4) greatly enhances phagocyte antimicrobial functions against a myriad of pathogens. In murine histoplasmosis, inhibition of the LT-generating enzyme 5-lypoxigenase (5-LO) increases the susceptibility of the host to infection. In this study, we investi...

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Bibliographic Details
Main Authors: Adriana Secatto, Elyara Maria Soares, Gisele Aparecida Locachevic, Patricia Aparecida Assis, Francisco Wanderlei Garcia Paula-Silva, Carlos Henrique Serezani, Alexandra Ivo de Medeiros, Lúcia Helena Faccioli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897419?pdf=render

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http://europepmc.org/articles/PMC3897419?pdf=render

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