The Inflammasome-Dependent Dysfunction and Death of Retinal Ganglion Cells after Repetitive Intraocular Pressure Spikes

The Inflammasome-Dependent Dysfunction and Death of Retinal Ganglion Cells after Repetitive Intraocular Pressure Spikes

The dysfunction and selective loss of retinal ganglion cells (RGCs) is a known cause of vision loss in glaucoma and other neuropathies, where ocular hypertension (OHT) is the major risk factor. We investigated the impact of transient non-ischemic OHT spikes (spOHT) on RGC function and viability in v...

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Bibliographic Details
Main Authors: Markus Spurlock, Weijun An, Galina Reshetnikova, Rong Wen, Hua Wang, Michelle Braha, Gabriela Solis, Stefan Kurtenbach, Orlando J. Galindez, Juan Pablo de Rivero Vaccari, Tsung-Han Chou, Vittorio Porciatti, Valery I. Shestopalov
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
ocular hypertension
intraocular pressure spikes
retinal ganglion cells
inflammasome
caspase-1
interleukin-1β
Online Access:https://www.mdpi.com/2073-4409/12/22/2626

Internet

https://www.mdpi.com/2073-4409/12/22/2626

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