Trabecular bone scores in young HIV-infected men: a matched case-control study
Abstract Background Screening for osteoporosis with dual-energy X-ray absorptiometry (DXA) is recommended for male HIV-infected patients only above the age of 50. Recently, trabecular bone score (TBS) has been introduced as a novel tool to assess bone microarchitecture using DXA of the lumbar spine....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-020-3092-0 |
| _version_ | 1811271182049083392 |
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| author | Youn Jeong Kim Kwi Young Kang Juyoung Shin Yoonhee Jun Sang Il Kim Yang Ree Kim |
| author_facet | Youn Jeong Kim Kwi Young Kang Juyoung Shin Yoonhee Jun Sang Il Kim Yang Ree Kim |
| author_sort | Youn Jeong Kim |
| collection | DOAJ |
| description | Abstract Background Screening for osteoporosis with dual-energy X-ray absorptiometry (DXA) is recommended for male HIV-infected patients only above the age of 50. Recently, trabecular bone score (TBS) has been introduced as a novel tool to assess bone microarchitecture using DXA of the lumbar spine. Few studies have reported TBS values in HIV-infected individuals younger than 50 years of age. This study compared TBS values in young males infected with HIV and matched controls, and investigated the associations between TBS and demographic parameters, clinical parameters, and bone mineral density (BMD) scores. Methods A cross-sectional study of BMD and TBS in HIV-infected men (n = 80) aged between 18 and 50 years and age- and sex-matched controls (n = 80) was conducted. Results The proportion of patients with low BMD (Z-score ≤ − 2) was significantly greater among HIV-infected patients than among matched controls (21.3% [17/80] vs. 8.8% [7/80], p = 0.027). Mean TBS values were significantly lower in HIV-infected patients than in controls (1.41 ± 0.07 vs. 1.45 ± 0.07, p = 0.008). In both groups, TBS values were positively correlated with BMD at the lumbar spine, femoral neck, and total hip (p < 0.001); however, TBS was not correlated with body mass index. In the HIV group, TBS was negatively correlated with the duration of tenofovir disoproxil fumarate(TDF) exposure (p = 0.04). Conclusion Young men infected with HIV had abnormal bone trabecular microarchitecture, as assessed by both TBS and BMD. TBS values were correlated with both BMD and the duration of TDF exposure. |
| first_indexed | 2024-04-12T22:15:33Z |
| format | Article |
| id | doaj.art-b7c1717550d94f3db79fd8f91e018629 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-12T22:15:33Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-b7c1717550d94f3db79fd8f91e0186292022-12-22T03:14:33ZengBMCBMC Musculoskeletal Disorders1471-24742020-02-012111810.1186/s12891-020-3092-0Trabecular bone scores in young HIV-infected men: a matched case-control studyYoun Jeong Kim0Kwi Young Kang1Juyoung Shin2Yoonhee Jun3Sang Il Kim4Yang Ree Kim5Division of Infectious Disease, Department of Internal Medicine, College of Medicine, The Catholic University of KoreaDepartment of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaHealth Promotion Center, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Infectious Disease, Department of Internal Medicine, College of Medicine, The Catholic University of KoreaDivision of Infectious Disease, Department of Internal Medicine, College of Medicine, The Catholic University of KoreaDivision of Infectious Disease, Department of Internal Medicine, College of Medicine, The Catholic University of KoreaAbstract Background Screening for osteoporosis with dual-energy X-ray absorptiometry (DXA) is recommended for male HIV-infected patients only above the age of 50. Recently, trabecular bone score (TBS) has been introduced as a novel tool to assess bone microarchitecture using DXA of the lumbar spine. Few studies have reported TBS values in HIV-infected individuals younger than 50 years of age. This study compared TBS values in young males infected with HIV and matched controls, and investigated the associations between TBS and demographic parameters, clinical parameters, and bone mineral density (BMD) scores. Methods A cross-sectional study of BMD and TBS in HIV-infected men (n = 80) aged between 18 and 50 years and age- and sex-matched controls (n = 80) was conducted. Results The proportion of patients with low BMD (Z-score ≤ − 2) was significantly greater among HIV-infected patients than among matched controls (21.3% [17/80] vs. 8.8% [7/80], p = 0.027). Mean TBS values were significantly lower in HIV-infected patients than in controls (1.41 ± 0.07 vs. 1.45 ± 0.07, p = 0.008). In both groups, TBS values were positively correlated with BMD at the lumbar spine, femoral neck, and total hip (p < 0.001); however, TBS was not correlated with body mass index. In the HIV group, TBS was negatively correlated with the duration of tenofovir disoproxil fumarate(TDF) exposure (p = 0.04). Conclusion Young men infected with HIV had abnormal bone trabecular microarchitecture, as assessed by both TBS and BMD. TBS values were correlated with both BMD and the duration of TDF exposure.https://doi.org/10.1186/s12891-020-3092-0Bone microarchitectureHIVTrabecular bone score |
| spellingShingle | Youn Jeong Kim Kwi Young Kang Juyoung Shin Yoonhee Jun Sang Il Kim Yang Ree Kim Trabecular bone scores in young HIV-infected men: a matched case-control study BMC Musculoskeletal Disorders Bone microarchitecture HIV Trabecular bone score |
| title | Trabecular bone scores in young HIV-infected men: a matched case-control study |
| title_full | Trabecular bone scores in young HIV-infected men: a matched case-control study |
| title_fullStr | Trabecular bone scores in young HIV-infected men: a matched case-control study |
| title_full_unstemmed | Trabecular bone scores in young HIV-infected men: a matched case-control study |
| title_short | Trabecular bone scores in young HIV-infected men: a matched case-control study |
| title_sort | trabecular bone scores in young hiv infected men a matched case control study |
| topic | Bone microarchitecture HIV Trabecular bone score |
| url | https://doi.org/10.1186/s12891-020-3092-0 |
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