Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities

The combretastatin D series and its analogues, corniculatolides and isocorniculatolides belong to a class of macrocycles called cyclic diaryl ether heptanoids (DAEH). This review is intended to highlight the structure elucidation, biosynthesis, and biological activity of these compounds as well as t...

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Main Authors: Jorge de Lima Neto, Paulo Henrique Menezes
Format: Article
Language:English
Published: Beilstein-Institut 2023-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.19.31
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author Jorge de Lima Neto
Paulo Henrique Menezes
author_facet Jorge de Lima Neto
Paulo Henrique Menezes
author_sort Jorge de Lima Neto
collection DOAJ
description The combretastatin D series and its analogues, corniculatolides and isocorniculatolides belong to a class of macrocycles called cyclic diaryl ether heptanoids (DAEH). This review is intended to highlight the structure elucidation, biosynthesis, and biological activity of these compounds as well as the use of different strategies for their synthesis.
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spelling doaj.art-b7c1d2ad45a84e9e9a92df0a77b2a5942023-04-04T13:41:08ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972023-03-0119139942710.3762/bjoc.19.311860-5397-19-31Combretastatins D series and analogues: from isolation, synthetic challenges and biological activitiesJorge de Lima Neto0Paulo Henrique Menezes1Universidade Federal de Pernambuco, Departamento de Química Fundamental, Recife-PE, 50740-560, Brazil Universidade Federal de Pernambuco, Departamento de Química Fundamental, Recife-PE, 50740-560, Brazil The combretastatin D series and its analogues, corniculatolides and isocorniculatolides belong to a class of macrocycles called cyclic diaryl ether heptanoids (DAEH). This review is intended to highlight the structure elucidation, biosynthesis, and biological activity of these compounds as well as the use of different strategies for their synthesis.https://doi.org/10.3762/bjoc.19.31combretastatin dcorniculatolideisocorniculatolidemacrocycles
spellingShingle Jorge de Lima Neto
Paulo Henrique Menezes
Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities
Beilstein Journal of Organic Chemistry
combretastatin d
corniculatolide
isocorniculatolide
macrocycles
title Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities
title_full Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities
title_fullStr Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities
title_full_unstemmed Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities
title_short Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities
title_sort combretastatins d series and analogues from isolation synthetic challenges and biological activities
topic combretastatin d
corniculatolide
isocorniculatolide
macrocycles
url https://doi.org/10.3762/bjoc.19.31
work_keys_str_mv AT jorgedelimaneto combretastatinsdseriesandanaloguesfromisolationsyntheticchallengesandbiologicalactivities
AT paulohenriquemenezes combretastatinsdseriesandanaloguesfromisolationsyntheticchallengesandbiologicalactivities