Evaluation of the Immunological Efficacy of an LNP-mRNA Vaccine Prepared from Varicella Zoster Virus Glycoprotein gE with a Double-Mutated Carboxyl Terminus in Different Untranslated Regions in Mice

Evaluation of the Immunological Efficacy of an LNP-mRNA Vaccine Prepared from Varicella Zoster Virus Glycoprotein gE with a Double-Mutated Carboxyl Terminus in Different Untranslated Regions in Mice

Cell-mediated immunity (CMI) plays a key role in the effectiveness of varicella zoster virus (VZV) vaccines, and mRNA vaccines have an innate advantage in inducing CMI. Glycoprotein E (gE) has been used widely as an antigen for VZV vaccines, and carboxyl-terminal mutations of gE are associated with...

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Bibliographic Details
Main Authors: Yunfei Wang, Han Cao, Kangyang Lin, Jingping Hu, Ning Luan, Cunbao Liu
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Vaccines
Subjects:
VZV
mRNA vaccine
CMI
UTR
Online Access:https://www.mdpi.com/2076-393X/11/9/1475

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