Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines

Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines

Summary: In normal intestines, a fetal/regenerative/revival cell state can be induced upon inflammation. This plasticity in cell fate is also one of the current topics in human colorectal cancer (CRC). To dissect the underlying mechanisms, we generated human CRC organoids with naturally selected gen...

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Bibliographic Details
Main Authors: Nobuhiko Ogasawara, Yoshihito Kano, Yosuke Yoneyama, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Fausto D. Velez-Bravo, Yourae Hong, Aleksandra Ostapiuk, Pavlo Lutsik, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Yusuke Kinugasa, Kenichi Ohashi, Mamoru Watanabe, Ryuichi Okamoto, Sabine Tejpar, Shiro Yui
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:iScience
Subjects:
Classification Description
Cancer
Stem cell plasticity
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224004681

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