Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer
Colorectal cancer (CRC) is a genetically heterogeneous disease that develops and progresses through several distinct pathways characterized by genomic instability. In recent years, it has emerged that inherent phenotypic plasticity in some populations of CRC cells can contribute to heterogeneity in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00013/full |
| _version_ | 1819237866260135936 |
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| author | Lloyd ePereira John eMariadason Ross eHannan Ross eHannan Ross eHannan Amardeep Singh Dhillon Amardeep Singh Dhillon Amardeep Singh Dhillon |
| author_facet | Lloyd ePereira John eMariadason Ross eHannan Ross eHannan Ross eHannan Amardeep Singh Dhillon Amardeep Singh Dhillon Amardeep Singh Dhillon |
| author_sort | Lloyd ePereira |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a genetically heterogeneous disease that develops and progresses through several distinct pathways characterized by genomic instability. In recent years, it has emerged that inherent phenotypic plasticity in some populations of CRC cells can contribute to heterogeneity in differentiation state, metastatic potential, therapeutic response and disease relapse. Such plasticity is thought to arise through interactions between aberrant signaling events, including persistent activation of the APC/β-catenin and KRAS/BRAF/ERK pathways, and the tumour microenvironment. Here, we highlight key concepts and evidence relating to the role of epithelial-mesenchymal plasticity as a driver of CRC progression and stratification of the disease into distinct molecular and clinicopathological subsets. |
| first_indexed | 2024-12-23T13:27:08Z |
| format | Article |
| id | doaj.art-b7c57d006bdb40f5bca86b8013e04413 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T13:27:08Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b7c57d006bdb40f5bca86b8013e044132022-12-21T17:45:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-02-01510.3389/fonc.2015.00013125370Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancerLloyd ePereira0John eMariadason1Ross eHannan2Ross eHannan3Ross eHannan4Amardeep Singh Dhillon5Amardeep Singh Dhillon6Amardeep Singh Dhillon7Peter MacCallum Cancer CentreOlivia Newton-John Cancer Research Institute, Austin HospitalPeter MacCallum Cancer CentreUniversity of MelbourneUniversity of MelbournePeter MacCallum Cancer CentreOlivia Newton-John Cancer Research Institute, Austin HospitalUniversity of MelbourneColorectal cancer (CRC) is a genetically heterogeneous disease that develops and progresses through several distinct pathways characterized by genomic instability. In recent years, it has emerged that inherent phenotypic plasticity in some populations of CRC cells can contribute to heterogeneity in differentiation state, metastatic potential, therapeutic response and disease relapse. Such plasticity is thought to arise through interactions between aberrant signaling events, including persistent activation of the APC/β-catenin and KRAS/BRAF/ERK pathways, and the tumour microenvironment. Here, we highlight key concepts and evidence relating to the role of epithelial-mesenchymal plasticity as a driver of CRC progression and stratification of the disease into distinct molecular and clinicopathological subsets.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00013/fullEpithelial-Mesenchymal TransitionCancer stem cellCRCsubtypesTumour progressionSerrated |
| spellingShingle | Lloyd ePereira John eMariadason Ross eHannan Ross eHannan Ross eHannan Amardeep Singh Dhillon Amardeep Singh Dhillon Amardeep Singh Dhillon Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer Frontiers in Oncology Epithelial-Mesenchymal Transition Cancer stem cell CRC subtypes Tumour progression Serrated |
| title | Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer |
| title_full | Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer |
| title_fullStr | Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer |
| title_full_unstemmed | Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer |
| title_short | Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer |
| title_sort | implications of epithelial mesenchymal plasticity for heterogeneity in colorectal cancer |
| topic | Epithelial-Mesenchymal Transition Cancer stem cell CRC subtypes Tumour progression Serrated |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00013/full |
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