Selectively increasing GHS-R1a expression in dCA1 excitatory/inhibitory neurons have opposite effects on memory encoding

Selectively increasing GHS-R1a expression in dCA1 excitatory/inhibitory neurons have opposite effects on memory encoding

Abstract Aim Growth hormone secretagogue receptor 1a (GHS-R1a) is widely distributed in brain including the hippocampus. Studies have demonstrated the critical role of hippocampal ghrelin/GHS-R1a signaling in synaptic physiology, memory and cognitive dysfunction associated with Alzheimer’s disease (...

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Bibliographic Details
Main Authors: Nan Li, Na Li, Fenghua Xu, Ming Yu, Zichen Qiao, Yu Zhou
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Molecular Brain
Subjects:
GHS-R1a
Ghrelin
Memory
Hippocampus
Interneuron
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s13041-021-00866-8

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