Computational reconstruction of iron- and manganese-responsive transcriptional networks in alpha-proteobacteria.
We used comparative genomics to investigate the distribution of conserved DNA-binding motifs in the regulatory regions of genes involved in iron and manganese homeostasis in alpha-proteobacteria. Combined with other computational approaches, this allowed us to reconstruct the metal regulatory networ...
Main Authors: | Dmitry A Rodionov, Mikhail S Gelfand, Jonathan D Todd, Andrew R J Curson, Andrew W B Johnston |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2006-12-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.0020163 |
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