Do Serum Galectin-9 Levels in Women with Gestational Diabetes and Healthy Ones Differ before or after Delivery? A Pilot Study
Gestational diabetes mellitus (GDM) is a common metabolic disease that occurs during pregnancy, with the placenta playing an important role in its pathophysiology. Currently, the role of galectin-9 in the development of GDM is unknown. The aim of this study was to compare galectin-9 concentrations i...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/4/697 |
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| author | Aleksandra Pełech Monika Ruszała Magdalena Niebrzydowska-Tatus Katarzyna Bień Żaneta Kimber-Trojnar Monika Czuba Małgorzata Świstowska Bożena Leszczyńska-Gorzelak |
| author_facet | Aleksandra Pełech Monika Ruszała Magdalena Niebrzydowska-Tatus Katarzyna Bień Żaneta Kimber-Trojnar Monika Czuba Małgorzata Świstowska Bożena Leszczyńska-Gorzelak |
| author_sort | Aleksandra Pełech |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is a common metabolic disease that occurs during pregnancy, with the placenta playing an important role in its pathophysiology. Currently, the role of galectin-9 in the development of GDM is unknown. The aim of this study was to compare galectin-9 concentrations in healthy pregnant women and those with GDM. Galectin-9 levels were assessed in serum samples taken both just before and after delivery, as well as in urine samples collected in the postpartum period. Maternal body composition and hydration status were evaluated using the bioelectrical impedance analysis (BIA) method. There were no statistically significant differences in the concentration of galectin-9 in women with GDM compared to healthy pregnant women in their serum samples taken just before delivery, nor in their serum and urine samples collected in the early postpartum period. However, serum galectin-9 concentrations taken before delivery were positively correlated with BMI and parameters related to the amount of adipose tissue assessed in the early postpartum period. Additionally, there was a correlation between serum galectin-9 concentrations taken before and after delivery. Galectin-9 is unlikely to become a diagnostic marker for GDM. However, this subject requires further clinical research in larger groups. |
| first_indexed | 2024-03-11T05:12:18Z |
| format | Article |
| id | doaj.art-b7c70f9c34644dd49e941f62fdf1a99a |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T05:12:18Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-b7c70f9c34644dd49e941f62fdf1a99a2023-11-17T18:30:04ZengMDPI AGBiomolecules2218-273X2023-04-0113469710.3390/biom13040697Do Serum Galectin-9 Levels in Women with Gestational Diabetes and Healthy Ones Differ before or after Delivery? A Pilot StudyAleksandra Pełech0Monika Ruszała1Magdalena Niebrzydowska-Tatus2Katarzyna Bień3Żaneta Kimber-Trojnar4Monika Czuba5Małgorzata Świstowska6Bożena Leszczyńska-Gorzelak7Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Clinical Genetics, Medical University of Lublin, 20-080 Lublin, PolandDepartment of Clinical Genetics, Medical University of Lublin, 20-080 Lublin, PolandDepartment of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, PolandGestational diabetes mellitus (GDM) is a common metabolic disease that occurs during pregnancy, with the placenta playing an important role in its pathophysiology. Currently, the role of galectin-9 in the development of GDM is unknown. The aim of this study was to compare galectin-9 concentrations in healthy pregnant women and those with GDM. Galectin-9 levels were assessed in serum samples taken both just before and after delivery, as well as in urine samples collected in the postpartum period. Maternal body composition and hydration status were evaluated using the bioelectrical impedance analysis (BIA) method. There were no statistically significant differences in the concentration of galectin-9 in women with GDM compared to healthy pregnant women in their serum samples taken just before delivery, nor in their serum and urine samples collected in the early postpartum period. However, serum galectin-9 concentrations taken before delivery were positively correlated with BMI and parameters related to the amount of adipose tissue assessed in the early postpartum period. Additionally, there was a correlation between serum galectin-9 concentrations taken before and after delivery. Galectin-9 is unlikely to become a diagnostic marker for GDM. However, this subject requires further clinical research in larger groups.https://www.mdpi.com/2218-273X/13/4/697galectin-9gestational diabetes mellitusbioelectrical impedance analysispregnancy |
| spellingShingle | Aleksandra Pełech Monika Ruszała Magdalena Niebrzydowska-Tatus Katarzyna Bień Żaneta Kimber-Trojnar Monika Czuba Małgorzata Świstowska Bożena Leszczyńska-Gorzelak Do Serum Galectin-9 Levels in Women with Gestational Diabetes and Healthy Ones Differ before or after Delivery? A Pilot Study Biomolecules galectin-9 gestational diabetes mellitus bioelectrical impedance analysis pregnancy |
| title | Do Serum Galectin-9 Levels in Women with Gestational Diabetes and Healthy Ones Differ before or after Delivery? A Pilot Study |
| title_full | Do Serum Galectin-9 Levels in Women with Gestational Diabetes and Healthy Ones Differ before or after Delivery? A Pilot Study |
| title_fullStr | Do Serum Galectin-9 Levels in Women with Gestational Diabetes and Healthy Ones Differ before or after Delivery? A Pilot Study |
| title_full_unstemmed | Do Serum Galectin-9 Levels in Women with Gestational Diabetes and Healthy Ones Differ before or after Delivery? A Pilot Study |
| title_short | Do Serum Galectin-9 Levels in Women with Gestational Diabetes and Healthy Ones Differ before or after Delivery? A Pilot Study |
| title_sort | do serum galectin 9 levels in women with gestational diabetes and healthy ones differ before or after delivery a pilot study |
| topic | galectin-9 gestational diabetes mellitus bioelectrical impedance analysis pregnancy |
| url | https://www.mdpi.com/2218-273X/13/4/697 |
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