GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs
Albumin is derived from human or animal blood, and its ability to bind to a large number of endogenous or exogenous biomolecules makes it an ideal drug carrier. As a result, albumin-based drug delivery systems are increasingly being studied. With these in mind, detailed studies of the transport mech...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1329636/full |
| _version_ | 1797348576920076288 |
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| author | Qingzhi Ji Huimin Zhu Yuting Qin Ruiya Zhang Lei Wang Erhao Zhang Xiaorong Zhou Run Meng |
| author_facet | Qingzhi Ji Huimin Zhu Yuting Qin Ruiya Zhang Lei Wang Erhao Zhang Xiaorong Zhou Run Meng |
| author_sort | Qingzhi Ji |
| collection | DOAJ |
| description | Albumin is derived from human or animal blood, and its ability to bind to a large number of endogenous or exogenous biomolecules makes it an ideal drug carrier. As a result, albumin-based drug delivery systems are increasingly being studied. With these in mind, detailed studies of the transport mechanism of albumin-based drug carriers are particularly important. As albumin receptors, glycoprotein 60 (GP60) and secreted protein acidic and rich in cysteine (SPARC) play a crucial role in the delivery of albumin-based drug carriers. GP60 is expressed on vascular endothelial cells and enables albumin to cross the vascular endothelial cell layer, and SPARC is overexpressed in many types of tumor cells, while it is minimally expressed in normal tissue cells. Thus, this review supplements existing articles by detailing the research history and specific biological functions of GP60 or SPARC and research advances in the delivery of antitumor drugs using albumin as a carrier. Meanwhile, the deficiencies and future perspectives in the study of the interaction of albumin with GP60 and SPARC are also pointed out. |
| first_indexed | 2024-03-08T12:08:01Z |
| format | Article |
| id | doaj.art-b7c906bb72c641cd849a29e5c7580ea5 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T12:08:01Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-b7c906bb72c641cd849a29e5c7580ea52024-01-23T04:37:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-01-011510.3389/fphar.2024.13296361329636GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugsQingzhi Ji0Huimin Zhu1Yuting Qin2Ruiya Zhang3Lei Wang4Erhao Zhang5Xiaorong Zhou6Run Meng7School of Pharmacy, Yancheng Teachers University, Yancheng, ChinaSheyang County Comprehensive Inspection and Testing Center, Yancheng, ChinaSchool of Pharmacy, Yancheng Teachers University, Yancheng, ChinaDepartment of Immunology, Medical School, Nantong University, Nantong, ChinaDepartment of Immunology, Medical School, Nantong University, Nantong, ChinaDepartment of Immunology, Medical School, Nantong University, Nantong, ChinaDepartment of Immunology, Medical School, Nantong University, Nantong, ChinaDepartment of Immunology, Medical School, Nantong University, Nantong, ChinaAlbumin is derived from human or animal blood, and its ability to bind to a large number of endogenous or exogenous biomolecules makes it an ideal drug carrier. As a result, albumin-based drug delivery systems are increasingly being studied. With these in mind, detailed studies of the transport mechanism of albumin-based drug carriers are particularly important. As albumin receptors, glycoprotein 60 (GP60) and secreted protein acidic and rich in cysteine (SPARC) play a crucial role in the delivery of albumin-based drug carriers. GP60 is expressed on vascular endothelial cells and enables albumin to cross the vascular endothelial cell layer, and SPARC is overexpressed in many types of tumor cells, while it is minimally expressed in normal tissue cells. Thus, this review supplements existing articles by detailing the research history and specific biological functions of GP60 or SPARC and research advances in the delivery of antitumor drugs using albumin as a carrier. Meanwhile, the deficiencies and future perspectives in the study of the interaction of albumin with GP60 and SPARC are also pointed out.https://www.frontiersin.org/articles/10.3389/fphar.2024.1329636/fullGP60SPARCalbumintarget deliverydrug carriers |
| spellingShingle | Qingzhi Ji Huimin Zhu Yuting Qin Ruiya Zhang Lei Wang Erhao Zhang Xiaorong Zhou Run Meng GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs Frontiers in Pharmacology GP60 SPARC albumin target delivery drug carriers |
| title | GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs |
| title_full | GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs |
| title_fullStr | GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs |
| title_full_unstemmed | GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs |
| title_short | GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs |
| title_sort | gp60 and sparc as albumin receptors key targeted sites for the delivery of antitumor drugs |
| topic | GP60 SPARC albumin target delivery drug carriers |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1329636/full |
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