The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments

The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments

Abstract Background The mitochondrial pyruvate carrier (MPC) plays a central role in energy metabolism by transporting pyruvate across the inner mitochondrial membrane. Its heterodimeric composition and homology to SWEET and semiSWEET transporters set the MPC apart from the canonical mitochondrial c...

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Bibliographic Details
Main Authors: Heike Rampelt, Iva Sucec, Beate Bersch, Patrick Horten, Inge Perschil, Jean-Claude Martinou, Martin van der Laan, Nils Wiedemann, Paul Schanda, Nikolaus Pfanner
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Biology
Subjects:
Mitochondrial pyruvate carrier
MPC
Mitochondrial protein biogenesis
Protein import
TIM22 complex
Tim9
Online Access:https://doi.org/10.1186/s12915-019-0733-6

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