The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer
Pancreatic cancer has the highest mortality rate of all major cancers, with a 5-year survival rate of about 10%. Early warning signs and symptoms of pancreatic cancer are vague or nonexistent, and most patients are diagnosed in Stage IV, when surgery is not an option for about 80%–85% of patients. F...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-12-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338221142472 |
| _version_ | 1827978092848611328 |
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| author | Peng Dong MM Yu Yan MM Yujun Fan PhD Hui Wang PhD Danzhu Wu MM Liyuan Yang MM Junpeng Zhang PhD Xiaoyang Yin PhD Yajuan Lv MD Jiandong Zhang MD Yuzhu Hou PhD Fengjun Liu MD Xinshuang Yu MD |
| author_facet | Peng Dong MM Yu Yan MM Yujun Fan PhD Hui Wang PhD Danzhu Wu MM Liyuan Yang MM Junpeng Zhang PhD Xiaoyang Yin PhD Yajuan Lv MD Jiandong Zhang MD Yuzhu Hou PhD Fengjun Liu MD Xinshuang Yu MD |
| author_sort | Peng Dong MM |
| collection | DOAJ |
| description | Pancreatic cancer has the highest mortality rate of all major cancers, with a 5-year survival rate of about 10%. Early warning signs and symptoms of pancreatic cancer are vague or nonexistent, and most patients are diagnosed in Stage IV, when surgery is not an option for about 80%–85% of patients. For patients with inoperable pancreatic cancer, current conventional treatment modalities such as chemotherapy and radiotherapy (RT) have suboptimal efficacy. Tumor progression is closely associated with the tumor microenvironment, which includes peripheral blood vessels, bone marrow-derived inflammatory cells, fibroblasts, immune cells, signaling molecules, and extracellular matrix. Tumor cells affect the microenvironment by releasing extracellular signaling molecules, inducing peripheral immune tolerance, and promoting tumor angiogenesis. In turn, the immune cells of the tumor affect the survival and proliferation of cancer cells. Myeloid-derived suppressor cells are key cellular components in the tumor microenvironment and exert immunosuppressive functions by producing cytokines, recognizing other immune cells, and promoting tumor growth and metastasis. Myeloid-derived suppressor cells are the main regulator of the tumor immune response and a key target for tumor treatments. Since the combination of RT and immunotherapy is the main strategy for the treatment of pancreatic cancer, it is very important to understand the immune mechanisms which lead to MDSCs generation and the failure of current therapies in order to develop new target-based therapies. This review summarizes the research advances on the role of Myeloid-derived suppressor cells in the progression of pancreatic cancer and its treatment application in recent years. |
| first_indexed | 2024-04-09T21:16:36Z |
| format | Article |
| id | doaj.art-b7cad0d6b1264679bd6669c3cfa121bb |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-09T21:16:36Z |
| publishDate | 2022-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-b7cad0d6b1264679bd6669c3cfa121bb2023-03-28T09:04:39ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382022-12-012110.1177/15330338221142472The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic CancerPeng Dong MM0Yu Yan MM1Yujun Fan PhD2Hui Wang PhD3Danzhu Wu MM4Liyuan Yang MM5Junpeng Zhang PhD6Xiaoyang Yin PhD7Yajuan Lv MD8Jiandong Zhang MD9Yuzhu Hou PhD10Fengjun Liu MD11Xinshuang Yu MD12 Department of oncology, , Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Shandong, China Department of oncology, , Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Shandong, China Medical Management Center，, Jinan, Shandong, China Department of oncology, , Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Shandong, China Department of Oncology, Clinical Medical College of Jining Medical University, Jining, Shandong, China Department of oncology, , Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Shandong, China Department of Oncology, The Second Hospital, Cheeloo College of Medicine Shandong University, Jinan, China Department of Radiation Oncology, Shandong Cancer Hospital and Institute, , Jinan, China Department of oncology, , Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Shandong, China Department of oncology, , Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Shandong, China Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, ShaanXi, China Department of oncology, , Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Shandong, China Department of oncology, , Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Shandong, ChinaPancreatic cancer has the highest mortality rate of all major cancers, with a 5-year survival rate of about 10%. Early warning signs and symptoms of pancreatic cancer are vague or nonexistent, and most patients are diagnosed in Stage IV, when surgery is not an option for about 80%–85% of patients. For patients with inoperable pancreatic cancer, current conventional treatment modalities such as chemotherapy and radiotherapy (RT) have suboptimal efficacy. Tumor progression is closely associated with the tumor microenvironment, which includes peripheral blood vessels, bone marrow-derived inflammatory cells, fibroblasts, immune cells, signaling molecules, and extracellular matrix. Tumor cells affect the microenvironment by releasing extracellular signaling molecules, inducing peripheral immune tolerance, and promoting tumor angiogenesis. In turn, the immune cells of the tumor affect the survival and proliferation of cancer cells. Myeloid-derived suppressor cells are key cellular components in the tumor microenvironment and exert immunosuppressive functions by producing cytokines, recognizing other immune cells, and promoting tumor growth and metastasis. Myeloid-derived suppressor cells are the main regulator of the tumor immune response and a key target for tumor treatments. Since the combination of RT and immunotherapy is the main strategy for the treatment of pancreatic cancer, it is very important to understand the immune mechanisms which lead to MDSCs generation and the failure of current therapies in order to develop new target-based therapies. This review summarizes the research advances on the role of Myeloid-derived suppressor cells in the progression of pancreatic cancer and its treatment application in recent years.https://doi.org/10.1177/15330338221142472 |
| spellingShingle | Peng Dong MM Yu Yan MM Yujun Fan PhD Hui Wang PhD Danzhu Wu MM Liyuan Yang MM Junpeng Zhang PhD Xiaoyang Yin PhD Yajuan Lv MD Jiandong Zhang MD Yuzhu Hou PhD Fengjun Liu MD Xinshuang Yu MD The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer Technology in Cancer Research & Treatment |
| title | The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer |
| title_full | The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer |
| title_fullStr | The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer |
| title_full_unstemmed | The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer |
| title_short | The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer |
| title_sort | role of myeloid derived suppressor cells in the treatment of pancreatic cancer |
| url | https://doi.org/10.1177/15330338221142472 |
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