Developing microRNA Screening as a Functional Genomics Tool for Disease Research
Originally discovered as regulators of developmental timing in C. elegans, microRNAs (miRNAs) have emerged as modulators of nearly every cellular process, from normal development to pathogenesis. With the advent of whole genome libraries of miRNA mimics suitable for high throughput screening, it is...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-08-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00223/full |
| _version_ | 1828827999098634240 |
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| author | Derek eLemons Derek eLemons Mano Ram Maurya Shankar eSubramaniam Mark eMercola Mark eMercola |
| author_facet | Derek eLemons Derek eLemons Mano Ram Maurya Shankar eSubramaniam Mark eMercola Mark eMercola |
| author_sort | Derek eLemons |
| collection | DOAJ |
| description | Originally discovered as regulators of developmental timing in C. elegans, microRNAs (miRNAs) have emerged as modulators of nearly every cellular process, from normal development to pathogenesis. With the advent of whole genome libraries of miRNA mimics suitable for high throughput screening, it is possible to comprehensively evaluate the function of each member of the miRNAome in cell-based assays. Since the relatively few microRNAs in the genome are thought to directly regulate a large portion of the proteome, miRNAome screening, coupled with the identification of the regulated proteins, might be a powerful new approach to gaining insight into complex biological processes. |
| first_indexed | 2024-12-12T15:12:32Z |
| format | Article |
| id | doaj.art-b7cbb907c3a440ca85d8905315b67c02 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T15:12:32Z |
| publishDate | 2013-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b7cbb907c3a440ca85d8905315b67c022022-12-22T00:20:35ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2013-08-01410.3389/fphys.2013.0022355704Developing microRNA Screening as a Functional Genomics Tool for Disease ResearchDerek eLemons0Derek eLemons1Mano Ram Maurya2Shankar eSubramaniam3Mark eMercola4Mark eMercola5University of California San DiegoSanford-Burnham Medical Research InstituteUniversity of California San DiegoUniversity of California San DiegoUniversity of California San DiegoSanford-Burnham Medical Research InstituteOriginally discovered as regulators of developmental timing in C. elegans, microRNAs (miRNAs) have emerged as modulators of nearly every cellular process, from normal development to pathogenesis. With the advent of whole genome libraries of miRNA mimics suitable for high throughput screening, it is possible to comprehensively evaluate the function of each member of the miRNAome in cell-based assays. Since the relatively few microRNAs in the genome are thought to directly regulate a large portion of the proteome, miRNAome screening, coupled with the identification of the regulated proteins, might be a powerful new approach to gaining insight into complex biological processes.http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00223/fullProteomicsFunctional Genomicsfunctional screensprotein-protein interactionsystems biology and network biologymicroRNA target |
| spellingShingle | Derek eLemons Derek eLemons Mano Ram Maurya Shankar eSubramaniam Mark eMercola Mark eMercola Developing microRNA Screening as a Functional Genomics Tool for Disease Research Frontiers in Physiology Proteomics Functional Genomics functional screens protein-protein interaction systems biology and network biology microRNA target |
| title | Developing microRNA Screening as a Functional Genomics Tool for Disease Research |
| title_full | Developing microRNA Screening as a Functional Genomics Tool for Disease Research |
| title_fullStr | Developing microRNA Screening as a Functional Genomics Tool for Disease Research |
| title_full_unstemmed | Developing microRNA Screening as a Functional Genomics Tool for Disease Research |
| title_short | Developing microRNA Screening as a Functional Genomics Tool for Disease Research |
| title_sort | developing microrna screening as a functional genomics tool for disease research |
| topic | Proteomics Functional Genomics functional screens protein-protein interaction systems biology and network biology microRNA target |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00223/full |
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