Elevated Expression of CAV1 is Associated with Unfavorable Prognosis of Patients with Breast Cancer Who Undergo Surgery and Neoadjuvant Chemotherapy
Jia-Hui Ye,1 Jia-Jun Shi,1 Xi Yin,1 Hong-Yan Wu,2 Xin-Yun Xu,2 Yong-Zhong Yao,1 Wei-Jie Zhang1 1General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 2Pathology Department, Nanjing Drum Towe...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/elevated-expression-of-cav1-is-associated-with-unfavorable-prognosis-o-peer-reviewed-article-CMAR |
| _version_ | 1818870140225191936 |
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| author | Ye JH Shi JJ Yin X Wu HY Xu XY Yao YZ Zhang WJ |
| author_facet | Ye JH Shi JJ Yin X Wu HY Xu XY Yao YZ Zhang WJ |
| author_sort | Ye JH |
| collection | DOAJ |
| description | Jia-Hui Ye,1 Jia-Jun Shi,1 Xi Yin,1 Hong-Yan Wu,2 Xin-Yun Xu,2 Yong-Zhong Yao,1 Wei-Jie Zhang1 1General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 2Pathology Department, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Wei-Jie Zhang; Yong-Zhong Yao No. 321 Zhonshan Road, Nanjing, Jiangsu, People’s Republic of ChinaTel +86 13770773971Fax +86 25-83105896Email zhangweijie1616@163.com; loyal1006@hotmail.comIntroduction: Neoadjuvant chemotherapy (NACT), which is standard treatment for locally advanced breast cancer, improves the resectability of patients with early breast cancer and reduces the extent of breast and axillary surgery. Caveolin-1 (CAV1) is implicated in human cancers, although its utility for cancer prognosis is unknown. Here, we investigated the expression of CAV1 in breast cancer tissues to evaluate its prognostic significance on patients with breast cancer administered NACT.Methods: CAV1 expression in 80 breast cancer tissue samples was evaluated using immunohistochemistry (IHC). The association between CAV1 levels and clinical factors was analyzed using the chi-square test and that between CAV1 and prognosis was evaluated using multivariate Cox regression and Kaplan–Meier analyses.Results: High levels of CAV1 were significantly associated with survival, and patients with overexpression of CAV1 had a poor prognosis. Adjusted multivariate Cox regression analyses revealed that a high level of CAV1 expression was an independent, significant prognostic factor for patients with breast cancer treated with NACT.Discussion: Overexpression of CAV1 in patients with breast cancer administered NACT was associated with shorter disease-free survival and overall survival. Therefore, high levels of CAV1 may serve as a prognostic biomarker for such patients.Keywords: CAV1, IHC, clinical outcome, biomarker |
| first_indexed | 2024-12-19T12:02:17Z |
| format | Article |
| id | doaj.art-b7cbcdcc863f429ea19ca61f7ba2b19b |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-19T12:02:17Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-b7cbcdcc863f429ea19ca61f7ba2b19b2022-12-21T20:22:28ZengDove Medical PressCancer Management and Research1179-13222020-09-01Volume 128887889257264Elevated Expression of CAV1 is Associated with Unfavorable Prognosis of Patients with Breast Cancer Who Undergo Surgery and Neoadjuvant ChemotherapyYe JHShi JJYin XWu HYXu XYYao YZZhang WJJia-Hui Ye,1 Jia-Jun Shi,1 Xi Yin,1 Hong-Yan Wu,2 Xin-Yun Xu,2 Yong-Zhong Yao,1 Wei-Jie Zhang1 1General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 2Pathology Department, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Wei-Jie Zhang; Yong-Zhong Yao No. 321 Zhonshan Road, Nanjing, Jiangsu, People’s Republic of ChinaTel +86 13770773971Fax +86 25-83105896Email zhangweijie1616@163.com; loyal1006@hotmail.comIntroduction: Neoadjuvant chemotherapy (NACT), which is standard treatment for locally advanced breast cancer, improves the resectability of patients with early breast cancer and reduces the extent of breast and axillary surgery. Caveolin-1 (CAV1) is implicated in human cancers, although its utility for cancer prognosis is unknown. Here, we investigated the expression of CAV1 in breast cancer tissues to evaluate its prognostic significance on patients with breast cancer administered NACT.Methods: CAV1 expression in 80 breast cancer tissue samples was evaluated using immunohistochemistry (IHC). The association between CAV1 levels and clinical factors was analyzed using the chi-square test and that between CAV1 and prognosis was evaluated using multivariate Cox regression and Kaplan–Meier analyses.Results: High levels of CAV1 were significantly associated with survival, and patients with overexpression of CAV1 had a poor prognosis. Adjusted multivariate Cox regression analyses revealed that a high level of CAV1 expression was an independent, significant prognostic factor for patients with breast cancer treated with NACT.Discussion: Overexpression of CAV1 in patients with breast cancer administered NACT was associated with shorter disease-free survival and overall survival. Therefore, high levels of CAV1 may serve as a prognostic biomarker for such patients.Keywords: CAV1, IHC, clinical outcome, biomarkerhttps://www.dovepress.com/elevated-expression-of-cav1-is-associated-with-unfavorable-prognosis-o-peer-reviewed-article-CMARcav1ihcclinical outcomebiomarker |
| spellingShingle | Ye JH Shi JJ Yin X Wu HY Xu XY Yao YZ Zhang WJ Elevated Expression of CAV1 is Associated with Unfavorable Prognosis of Patients with Breast Cancer Who Undergo Surgery and Neoadjuvant Chemotherapy Cancer Management and Research cav1 ihc clinical outcome biomarker |
| title | Elevated Expression of CAV1 is Associated with Unfavorable Prognosis of Patients with Breast Cancer Who Undergo Surgery and Neoadjuvant Chemotherapy |
| title_full | Elevated Expression of CAV1 is Associated with Unfavorable Prognosis of Patients with Breast Cancer Who Undergo Surgery and Neoadjuvant Chemotherapy |
| title_fullStr | Elevated Expression of CAV1 is Associated with Unfavorable Prognosis of Patients with Breast Cancer Who Undergo Surgery and Neoadjuvant Chemotherapy |
| title_full_unstemmed | Elevated Expression of CAV1 is Associated with Unfavorable Prognosis of Patients with Breast Cancer Who Undergo Surgery and Neoadjuvant Chemotherapy |
| title_short | Elevated Expression of CAV1 is Associated with Unfavorable Prognosis of Patients with Breast Cancer Who Undergo Surgery and Neoadjuvant Chemotherapy |
| title_sort | elevated expression of cav1 is associated with unfavorable prognosis of patients with breast cancer who undergo surgery and neoadjuvant chemotherapy |
| topic | cav1 ihc clinical outcome biomarker |
| url | https://www.dovepress.com/elevated-expression-of-cav1-is-associated-with-unfavorable-prognosis-o-peer-reviewed-article-CMAR |
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