Long-term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma: a propensity score matching analysis
BackgroundPortal vein tumor thrombus (PVTT) seriously affects the prognosis of hepatocellular carcinoma (HCC). However, whether bile duct tumor thrombus (BDTT) significantly affects the prognosis of HCC as much as PVTT remains unclear. We aimed to compare the long-term surgical outcomes of HCC with...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1372123/full |
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| author | Yi-Nan Li Yi-Nan Li Shao-Ming Wei Shao-Ming Wei Yang-Kai Fu Yang-Kai Fu Zhen-Xin Zeng Zhen-Xin Zeng Li-Ming Huang Li-Ming Huang Jia-Hui Lv Jia-Hui Lv Wei-Zhao Chen Wei-Zhao Chen Yong-Gang Wei Zhi-Bo Zhang Jian-Yin Zhou Jia-Yi Wu Jia-Yi Wu Mao-Lin Yan Mao-Lin Yan |
| author_facet | Yi-Nan Li Yi-Nan Li Shao-Ming Wei Shao-Ming Wei Yang-Kai Fu Yang-Kai Fu Zhen-Xin Zeng Zhen-Xin Zeng Li-Ming Huang Li-Ming Huang Jia-Hui Lv Jia-Hui Lv Wei-Zhao Chen Wei-Zhao Chen Yong-Gang Wei Zhi-Bo Zhang Jian-Yin Zhou Jia-Yi Wu Jia-Yi Wu Mao-Lin Yan Mao-Lin Yan |
| author_sort | Yi-Nan Li |
| collection | DOAJ |
| description | BackgroundPortal vein tumor thrombus (PVTT) seriously affects the prognosis of hepatocellular carcinoma (HCC). However, whether bile duct tumor thrombus (BDTT) significantly affects the prognosis of HCC as much as PVTT remains unclear. We aimed to compare the long-term surgical outcomes of HCC with macroscopic PVTT (macro-PVTT) and macroscopic BDTT (macro-BDTT).MethodsThe data of HCC patients with macro-BDTT or macro-PVTT who underwent hemihepatectomy were retrospectively reviewed. A propensity score matching (PSM) analysis was performed to reduce the baseline imbalance. The recurrence-free survival (RFS) and overall survival (OS) rates were compared between the cohorts.ResultsBefore PSM, the PVTT group had worse RFS and OS rates than the BDTT group (P = 0.043 and P = 0.008, respectively). Multivariate analyses identified PVTT (hazard ratio [HR] = 1.835, P = 0.016) and large HCC (HR = 1.553, P = 0.039) as independent risk factors for poor OS and RFS, respectively. After PSM, the PVTT group had worse RFS and OS rates than the BDTT group (P = 0.037 and P = 0.004, respectively). The 3- and 5-year OS rates were significantly higher in the BDTT group (59.5% and 52.1%, respectively) than in the PVTT group (33.3% and 20.2%, respectively).ConclusionAggressive hemihepatectomy provides an acceptable prognosis for HCC patients with macro-BDTT. Furthermore, the long-term surgical outcomes of HCC patients with macro-BDTT were significantly better than those of HCC patients with macro-PVTT. |
| first_indexed | 2024-04-24T15:29:08Z |
| format | Article |
| id | doaj.art-b7cbdbafadab443bb69bdc14066008b4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T15:29:08Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b7cbdbafadab443bb69bdc14066008b42024-04-02T04:56:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-04-011410.3389/fonc.2024.13721231372123Long-term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma: a propensity score matching analysisYi-Nan Li0Yi-Nan Li1Shao-Ming Wei2Shao-Ming Wei3Yang-Kai Fu4Yang-Kai Fu5Zhen-Xin Zeng6Zhen-Xin Zeng7Li-Ming Huang8Li-Ming Huang9Jia-Hui Lv10Jia-Hui Lv11Wei-Zhao Chen12Wei-Zhao Chen13Yong-Gang Wei14Zhi-Bo Zhang15Jian-Yin Zhou16Jia-Yi Wu17Jia-Yi Wu18Mao-Lin Yan19Mao-Lin Yan20Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, ChinaDepartment of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Hepatobiliary Surgery, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, ChinaBackgroundPortal vein tumor thrombus (PVTT) seriously affects the prognosis of hepatocellular carcinoma (HCC). However, whether bile duct tumor thrombus (BDTT) significantly affects the prognosis of HCC as much as PVTT remains unclear. We aimed to compare the long-term surgical outcomes of HCC with macroscopic PVTT (macro-PVTT) and macroscopic BDTT (macro-BDTT).MethodsThe data of HCC patients with macro-BDTT or macro-PVTT who underwent hemihepatectomy were retrospectively reviewed. A propensity score matching (PSM) analysis was performed to reduce the baseline imbalance. The recurrence-free survival (RFS) and overall survival (OS) rates were compared between the cohorts.ResultsBefore PSM, the PVTT group had worse RFS and OS rates than the BDTT group (P = 0.043 and P = 0.008, respectively). Multivariate analyses identified PVTT (hazard ratio [HR] = 1.835, P = 0.016) and large HCC (HR = 1.553, P = 0.039) as independent risk factors for poor OS and RFS, respectively. After PSM, the PVTT group had worse RFS and OS rates than the BDTT group (P = 0.037 and P = 0.004, respectively). The 3- and 5-year OS rates were significantly higher in the BDTT group (59.5% and 52.1%, respectively) than in the PVTT group (33.3% and 20.2%, respectively).ConclusionAggressive hemihepatectomy provides an acceptable prognosis for HCC patients with macro-BDTT. Furthermore, the long-term surgical outcomes of HCC patients with macro-BDTT were significantly better than those of HCC patients with macro-PVTT.https://www.frontiersin.org/articles/10.3389/fonc.2024.1372123/fullhepatocellular carcinomamacroscopic bile duct tumor thrombusmacroscopic portal vein tumor thrombusoverall survivalpropensity score matching analysis |
| spellingShingle | Yi-Nan Li Yi-Nan Li Shao-Ming Wei Shao-Ming Wei Yang-Kai Fu Yang-Kai Fu Zhen-Xin Zeng Zhen-Xin Zeng Li-Ming Huang Li-Ming Huang Jia-Hui Lv Jia-Hui Lv Wei-Zhao Chen Wei-Zhao Chen Yong-Gang Wei Zhi-Bo Zhang Jian-Yin Zhou Jia-Yi Wu Jia-Yi Wu Mao-Lin Yan Mao-Lin Yan Long-term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma: a propensity score matching analysis Frontiers in Oncology hepatocellular carcinoma macroscopic bile duct tumor thrombus macroscopic portal vein tumor thrombus overall survival propensity score matching analysis |
| title | Long-term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma: a propensity score matching analysis |
| title_full | Long-term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma: a propensity score matching analysis |
| title_fullStr | Long-term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma: a propensity score matching analysis |
| title_full_unstemmed | Long-term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma: a propensity score matching analysis |
| title_short | Long-term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma: a propensity score matching analysis |
| title_sort | long term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma a propensity score matching analysis |
| topic | hepatocellular carcinoma macroscopic bile duct tumor thrombus macroscopic portal vein tumor thrombus overall survival propensity score matching analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1372123/full |
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