PET Imaging in Animal Models of Alzheimer’s Disease
The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for in vivo detection of these hallmarks of Alzheimer’s disease (AD) antemortem. Amyloid and tau PET have been incorporated into the A/T/N scheme for AD chara...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.872509/full |
| _version_ | 1818006285975552000 |
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| author | Baosheng Chen Bernadette Marquez-Nostra Erika Belitzky Takuya Toyonaga Jie Tong Yiyun Huang Zhengxin Cai |
| author_facet | Baosheng Chen Bernadette Marquez-Nostra Erika Belitzky Takuya Toyonaga Jie Tong Yiyun Huang Zhengxin Cai |
| author_sort | Baosheng Chen |
| collection | DOAJ |
| description | The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for in vivo detection of these hallmarks of Alzheimer’s disease (AD) antemortem. Amyloid and tau PET have been incorporated into the A/T/N scheme for AD characterization and have become an integral part of ongoing clinical trials to screen patients for enrollment, prove drug action mechanisms, and monitor therapeutic effects. Meanwhile, preclinical PET imaging in animal models of AD can provide supportive information for mechanistic studies. With the recent advancement of gene editing technologies and AD animal model development, preclinical PET imaging in AD models will further facilitate our understanding of AD pathogenesis/progression and the development of novel treatments. In this study, we review the current state-of-the-art in preclinical PET imaging using animal models of AD and suggest future research directions. |
| first_indexed | 2024-04-14T04:59:59Z |
| format | Article |
| id | doaj.art-b7ce46781f354419a7158f69d0a251aa |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-14T04:59:59Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-b7ce46781f354419a7158f69d0a251aa2022-12-22T02:11:01ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-05-011610.3389/fnins.2022.872509872509PET Imaging in Animal Models of Alzheimer’s DiseaseBaosheng ChenBernadette Marquez-NostraErika BelitzkyTakuya ToyonagaJie TongYiyun HuangZhengxin CaiThe successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for in vivo detection of these hallmarks of Alzheimer’s disease (AD) antemortem. Amyloid and tau PET have been incorporated into the A/T/N scheme for AD characterization and have become an integral part of ongoing clinical trials to screen patients for enrollment, prove drug action mechanisms, and monitor therapeutic effects. Meanwhile, preclinical PET imaging in animal models of AD can provide supportive information for mechanistic studies. With the recent advancement of gene editing technologies and AD animal model development, preclinical PET imaging in AD models will further facilitate our understanding of AD pathogenesis/progression and the development of novel treatments. In this study, we review the current state-of-the-art in preclinical PET imaging using animal models of AD and suggest future research directions.https://www.frontiersin.org/articles/10.3389/fnins.2022.872509/fullpositron emission tomographyAlzheimer’s diseaseβ-amyloid (Aβ)tauneurodegenerationSV2A |
| spellingShingle | Baosheng Chen Bernadette Marquez-Nostra Erika Belitzky Takuya Toyonaga Jie Tong Yiyun Huang Zhengxin Cai PET Imaging in Animal Models of Alzheimer’s Disease Frontiers in Neuroscience positron emission tomography Alzheimer’s disease β-amyloid (Aβ) tau neurodegeneration SV2A |
| title | PET Imaging in Animal Models of Alzheimer’s Disease |
| title_full | PET Imaging in Animal Models of Alzheimer’s Disease |
| title_fullStr | PET Imaging in Animal Models of Alzheimer’s Disease |
| title_full_unstemmed | PET Imaging in Animal Models of Alzheimer’s Disease |
| title_short | PET Imaging in Animal Models of Alzheimer’s Disease |
| title_sort | pet imaging in animal models of alzheimer s disease |
| topic | positron emission tomography Alzheimer’s disease β-amyloid (Aβ) tau neurodegeneration SV2A |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.872509/full |
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