Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State
Elucidating the structure and function of the HIV-1 outer envelope proteins is critical for the design of an effective vaccine. Despite the availability of many high-resolution structures, key functional correlates in the envelope trimer remain undefined.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2021-04-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.00090-21 |
| _version_ | 1818394819165159424 |
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| author | Peng Zhang Alice L. Kwon Christina Guzzo Qingbo Liu Hana Schmeisser Huiyi Miao Yin Lin Raffaello Cimbro Jinghe Huang Mark Connors Stephen D. Schmidt Michael A. Dolan Anthony A. Armstrong Paolo Lusso |
| author_facet | Peng Zhang Alice L. Kwon Christina Guzzo Qingbo Liu Hana Schmeisser Huiyi Miao Yin Lin Raffaello Cimbro Jinghe Huang Mark Connors Stephen D. Schmidt Michael A. Dolan Anthony A. Armstrong Paolo Lusso |
| author_sort | Peng Zhang |
| collection | DOAJ |
| description | Elucidating the structure and function of the HIV-1 outer envelope proteins is critical for the design of an effective vaccine. Despite the availability of many high-resolution structures, key functional correlates in the envelope trimer remain undefined. |
| first_indexed | 2024-12-14T06:07:16Z |
| format | Article |
| id | doaj.art-b7ce808852144799b0fcfef045f0734b |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-14T06:07:16Z |
| publishDate | 2021-04-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-b7ce808852144799b0fcfef045f0734b2022-12-21T23:14:16ZengAmerican Society for MicrobiologymBio2150-75112021-04-0112210.1128/mBio.00090-21Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed StatePeng Zhang0Alice L. Kwon1Christina Guzzo2Qingbo Liu3Hana Schmeisser4Huiyi Miao5Yin Lin6Raffaello Cimbro7Jinghe Huang8Mark Connors9Stephen D. Schmidt10Michael A. Dolan11Anthony A. Armstrong12Paolo Lusso13https://orcid.org/0000-0002-2813-4081Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USALaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USALaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USALaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USALaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USALaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USALaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USADivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USALaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USALaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USAVaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USABioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USABioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USALaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USAElucidating the structure and function of the HIV-1 outer envelope proteins is critical for the design of an effective vaccine. Despite the availability of many high-resolution structures, key functional correlates in the envelope trimer remain undefined.https://journals.asm.org/doi/10.1128/mBio.00090-21 |
| spellingShingle | Peng Zhang Alice L. Kwon Christina Guzzo Qingbo Liu Hana Schmeisser Huiyi Miao Yin Lin Raffaello Cimbro Jinghe Huang Mark Connors Stephen D. Schmidt Michael A. Dolan Anthony A. Armstrong Paolo Lusso Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State mBio |
| title | Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
| title_full | Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
| title_fullStr | Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
| title_full_unstemmed | Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
| title_short | Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
| title_sort | functional anatomy of the trimer apex reveals key hydrophobic constraints that maintain the hiv 1 envelope spike in a closed state |
| url | https://journals.asm.org/doi/10.1128/mBio.00090-21 |
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