Trans-tail regulation-mediated suppression of cryptic transcription
Cell biology: Interaction of DNA-winding proteins ensures correct gene expression Crosstalk between different DNA-winding proteins, or histones, is a mechanism of molecular fidelity that helps prevent the initiation of aberrant gene expression, which may contribute to cancer and neurodegenerative di...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-11-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-021-00711-x |
| _version_ | 1818742187696848896 |
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| author | Jungmin Choi Zae Young Ryoo Dong-Hyung Cho Hyun-Shik Lee Hong-Yeoul Ryu |
| author_facet | Jungmin Choi Zae Young Ryoo Dong-Hyung Cho Hyun-Shik Lee Hong-Yeoul Ryu |
| author_sort | Jungmin Choi |
| collection | DOAJ |
| description | Cell biology: Interaction of DNA-winding proteins ensures correct gene expression Crosstalk between different DNA-winding proteins, or histones, is a mechanism of molecular fidelity that helps prevent the initiation of aberrant gene expression, which may contribute to cancer and neurodegenerative disease. A team from South Korea, led by Jungmin Choi from the Korea University College of Medicine in Seoul and Hong-Yeoul Ryu from Kyungpook National University in Daegu, review the ways in which different histone proteins chemically modify parts of each other’s structure to regulate their functions. These modifications affect how histones interact with DNA, which in turn alters the dynamics of other factors implicated in gene expression. The correct interaction of histones is necessary to prevent the gene expression machinery from starting RNA synthesis from the wrong sites. Accurate control of these mechanisms is essential for cellular wellbeing |
| first_indexed | 2024-12-18T02:08:32Z |
| format | Article |
| id | doaj.art-b7cf57632e8a48a381b88dd44b26e808 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-18T02:08:32Z |
| publishDate | 2021-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-b7cf57632e8a48a381b88dd44b26e8082022-12-21T21:24:32ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132021-11-0153111683168810.1038/s12276-021-00711-xTrans-tail regulation-mediated suppression of cryptic transcriptionJungmin Choi0Zae Young Ryoo1Dong-Hyung Cho2Hyun-Shik Lee3Hong-Yeoul Ryu4Department of Biomedical Sciences, Korea University College of MedicineBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National UniversityBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National UniversityBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National UniversityBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National UniversityCell biology: Interaction of DNA-winding proteins ensures correct gene expression Crosstalk between different DNA-winding proteins, or histones, is a mechanism of molecular fidelity that helps prevent the initiation of aberrant gene expression, which may contribute to cancer and neurodegenerative disease. A team from South Korea, led by Jungmin Choi from the Korea University College of Medicine in Seoul and Hong-Yeoul Ryu from Kyungpook National University in Daegu, review the ways in which different histone proteins chemically modify parts of each other’s structure to regulate their functions. These modifications affect how histones interact with DNA, which in turn alters the dynamics of other factors implicated in gene expression. The correct interaction of histones is necessary to prevent the gene expression machinery from starting RNA synthesis from the wrong sites. Accurate control of these mechanisms is essential for cellular wellbeinghttps://doi.org/10.1038/s12276-021-00711-x |
| spellingShingle | Jungmin Choi Zae Young Ryoo Dong-Hyung Cho Hyun-Shik Lee Hong-Yeoul Ryu Trans-tail regulation-mediated suppression of cryptic transcription Experimental and Molecular Medicine |
| title | Trans-tail regulation-mediated suppression of cryptic transcription |
| title_full | Trans-tail regulation-mediated suppression of cryptic transcription |
| title_fullStr | Trans-tail regulation-mediated suppression of cryptic transcription |
| title_full_unstemmed | Trans-tail regulation-mediated suppression of cryptic transcription |
| title_short | Trans-tail regulation-mediated suppression of cryptic transcription |
| title_sort | trans tail regulation mediated suppression of cryptic transcription |
| url | https://doi.org/10.1038/s12276-021-00711-x |
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