Survival of Self-Replicating Molecules under Transient Compartmentalization with Natural Selection
The problem of the emergence and survival of self-replicating molecules in origin-of-life scenarios is plagued by the error catastrophe, which is usually escaped by considering effects of compartmentalization, as in the stochastic corrector model. By addressing the problem in a simple system compose...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/9/4/78 |
| _version_ | 1817996293738332160 |
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| author | Gabin Laurent Luca Peliti David Lacoste |
| author_facet | Gabin Laurent Luca Peliti David Lacoste |
| author_sort | Gabin Laurent |
| collection | DOAJ |
| description | The problem of the emergence and survival of self-replicating molecules in origin-of-life scenarios is plagued by the error catastrophe, which is usually escaped by considering effects of compartmentalization, as in the stochastic corrector model. By addressing the problem in a simple system composed of a self-replicating molecule (a replicase) and a parasite molecule that needs the replicase for copying itself, we show that transient (rather than permanent) compartmentalization is sufficient to the task. We also exhibit a regime in which the concentrations of the two kinds of molecules undergo sustained oscillations. Our model should be relevant not only for origin-of-life scenarios but also for describing directed evolution experiments, which increasingly rely on transient compartmentalization with pooling and natural selection. |
| first_indexed | 2024-04-14T02:20:12Z |
| format | Article |
| id | doaj.art-b7d08a0e54c349c1aa88699501860786 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-04-14T02:20:12Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-b7d08a0e54c349c1aa886995018607862022-12-22T02:18:03ZengMDPI AGLife2075-17292019-10-01947810.3390/life9040078life9040078Survival of Self-Replicating Molecules under Transient Compartmentalization with Natural SelectionGabin Laurent0Luca Peliti1David Lacoste2UMR CNRS Gulliver 7083, ESPCI, 10 rue Vauquelin, CEDEX 05, 75231 Paris, FranceSanta Marinella Research Institute, 00052 Santa Marinella, ItalyUMR CNRS Gulliver 7083, ESPCI, 10 rue Vauquelin, CEDEX 05, 75231 Paris, FranceThe problem of the emergence and survival of self-replicating molecules in origin-of-life scenarios is plagued by the error catastrophe, which is usually escaped by considering effects of compartmentalization, as in the stochastic corrector model. By addressing the problem in a simple system composed of a self-replicating molecule (a replicase) and a parasite molecule that needs the replicase for copying itself, we show that transient (rather than permanent) compartmentalization is sufficient to the task. We also exhibit a regime in which the concentrations of the two kinds of molecules undergo sustained oscillations. Our model should be relevant not only for origin-of-life scenarios but also for describing directed evolution experiments, which increasingly rely on transient compartmentalization with pooling and natural selection.https://www.mdpi.com/2075-1729/9/4/78origin of lifeerror catastropheparasites |
| spellingShingle | Gabin Laurent Luca Peliti David Lacoste Survival of Self-Replicating Molecules under Transient Compartmentalization with Natural Selection Life origin of life error catastrophe parasites |
| title | Survival of Self-Replicating Molecules under Transient Compartmentalization with Natural Selection |
| title_full | Survival of Self-Replicating Molecules under Transient Compartmentalization with Natural Selection |
| title_fullStr | Survival of Self-Replicating Molecules under Transient Compartmentalization with Natural Selection |
| title_full_unstemmed | Survival of Self-Replicating Molecules under Transient Compartmentalization with Natural Selection |
| title_short | Survival of Self-Replicating Molecules under Transient Compartmentalization with Natural Selection |
| title_sort | survival of self replicating molecules under transient compartmentalization with natural selection |
| topic | origin of life error catastrophe parasites |
| url | https://www.mdpi.com/2075-1729/9/4/78 |
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