The Functional Neuroanatomy of Brain Cannabinoid Receptors
The effects of the primary psychoactive constituent of marijuana, Δ9-tetrahydrocannabinol, are mediated by cannabinoid receptors, CB1 and CB2. The CB1 receptors display a unique central nervous system (CNS) distribution and are present in mammalian brain at higher levels than most other known G-prot...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1998-12-01
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| Series: | Neurobiology of Disease |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996198902297 |
| _version_ | 1818677469996122112 |
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| author | Christopher S. Breivogel Steven R. Childers |
| author_facet | Christopher S. Breivogel Steven R. Childers |
| author_sort | Christopher S. Breivogel |
| collection | DOAJ |
| description | The effects of the primary psychoactive constituent of marijuana, Δ9-tetrahydrocannabinol, are mediated by cannabinoid receptors, CB1 and CB2. The CB1 receptors display a unique central nervous system (CNS) distribution and are present in mammalian brain at higher levels than most other known G-protein-coupled receptors. The highest levels occur in several areas involved in motor control and hippocampus. Cannabinoid effects on CNS activities, including movement, memory, nociception, endocrine regulation, thermoregulation, sensory perception, cognitive functions, and mood, correlate with the regional distribution of cannabinoid receptors and their activation of specific G-protein-mediated signal transduction systems in various brain regions. |
| first_indexed | 2024-12-17T08:59:52Z |
| format | Article |
| id | doaj.art-b7d0cc12f4714c98b67d9c96494744ed |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-17T08:59:52Z |
| publishDate | 1998-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-b7d0cc12f4714c98b67d9c96494744ed2022-12-21T21:55:47ZengElsevierNeurobiology of Disease1095-953X1998-12-0156417431The Functional Neuroanatomy of Brain Cannabinoid ReceptorsChristopher S. Breivogel0Steven R. Childers1Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina, 27157Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina, 27157The effects of the primary psychoactive constituent of marijuana, Δ9-tetrahydrocannabinol, are mediated by cannabinoid receptors, CB1 and CB2. The CB1 receptors display a unique central nervous system (CNS) distribution and are present in mammalian brain at higher levels than most other known G-protein-coupled receptors. The highest levels occur in several areas involved in motor control and hippocampus. Cannabinoid effects on CNS activities, including movement, memory, nociception, endocrine regulation, thermoregulation, sensory perception, cognitive functions, and mood, correlate with the regional distribution of cannabinoid receptors and their activation of specific G-protein-mediated signal transduction systems in various brain regions.http://www.sciencedirect.com/science/article/pii/S0969996198902297 |
| spellingShingle | Christopher S. Breivogel Steven R. Childers The Functional Neuroanatomy of Brain Cannabinoid Receptors Neurobiology of Disease |
| title | The Functional Neuroanatomy of Brain Cannabinoid Receptors |
| title_full | The Functional Neuroanatomy of Brain Cannabinoid Receptors |
| title_fullStr | The Functional Neuroanatomy of Brain Cannabinoid Receptors |
| title_full_unstemmed | The Functional Neuroanatomy of Brain Cannabinoid Receptors |
| title_short | The Functional Neuroanatomy of Brain Cannabinoid Receptors |
| title_sort | functional neuroanatomy of brain cannabinoid receptors |
| url | http://www.sciencedirect.com/science/article/pii/S0969996198902297 |
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