Aluminum toxicity induced Alzheimer’s Disease and its potential treatment using antioxidants - a review
Abstract Over the years, a handful of drugs have been approved to be used in the fight against Alzheimer’s Disease but unfortunately none of these drugs have proven to be solid-treatments. Alzheimer’s Disease is one of the most prominent diseases observed in the elderly population. In this review ar...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade de São Paulo
2023-11-01
|
| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100800&tlng=en |
| _version_ | 1797635131493580800 |
|---|---|
| author | Rishi Choudhury Harsha Ashtekar Kartik B. Khot Magrita Malngiang Merugumolu Vijay Kumar Soumi Mandal Barnali Das |
| author_facet | Rishi Choudhury Harsha Ashtekar Kartik B. Khot Magrita Malngiang Merugumolu Vijay Kumar Soumi Mandal Barnali Das |
| author_sort | Rishi Choudhury |
| collection | DOAJ |
| description | Abstract Over the years, a handful of drugs have been approved to be used in the fight against Alzheimer’s Disease but unfortunately none of these drugs have proven to be solid-treatments. Alzheimer’s Disease is one of the most prominent diseases observed in the elderly population. In this review article, we discuss how aluminum toxicity can lead to neuro degeneration. Aluminum is abundantly present on the earth’s crust and hence becomes easily accessible to man. This makes it an obvious choice in the preparation of numerous substances, packaging, etc. Such wide usage of the metal can pave an easy access to the body, leading to toxicities. Aluminum toxicity has been linked to oxidative stress which has an established relation with neurodegeneration and mitochondrial damage. We also discuss how consumption of antioxidants can be useful in combating oxidative stress. |
| first_indexed | 2024-03-11T12:16:59Z |
| format | Article |
| id | doaj.art-b7d0de73f46c47af8e41c8ae8aa4bec6 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-03-11T12:16:59Z |
| publishDate | 2023-11-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-b7d0de73f46c47af8e41c8ae8aa4bec62023-11-07T07:44:32ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902023-11-015910.1590/s2175-97902023e21587Aluminum toxicity induced Alzheimer’s Disease and its potential treatment using antioxidants - a reviewRishi ChoudhuryHarsha AshtekarKartik B. KhotMagrita MalngiangMerugumolu Vijay Kumarhttps://orcid.org/0000-0002-8366-6312Soumi MandalBarnali DasAbstract Over the years, a handful of drugs have been approved to be used in the fight against Alzheimer’s Disease but unfortunately none of these drugs have proven to be solid-treatments. Alzheimer’s Disease is one of the most prominent diseases observed in the elderly population. In this review article, we discuss how aluminum toxicity can lead to neuro degeneration. Aluminum is abundantly present on the earth’s crust and hence becomes easily accessible to man. This makes it an obvious choice in the preparation of numerous substances, packaging, etc. Such wide usage of the metal can pave an easy access to the body, leading to toxicities. Aluminum toxicity has been linked to oxidative stress which has an established relation with neurodegeneration and mitochondrial damage. We also discuss how consumption of antioxidants can be useful in combating oxidative stress.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100800&tlng=enAlzheimer’s DiseaseAluminumToxicityOxidative stressNeurodegeneration |
| spellingShingle | Rishi Choudhury Harsha Ashtekar Kartik B. Khot Magrita Malngiang Merugumolu Vijay Kumar Soumi Mandal Barnali Das Aluminum toxicity induced Alzheimer’s Disease and its potential treatment using antioxidants - a review Brazilian Journal of Pharmaceutical Sciences Alzheimer’s Disease Aluminum Toxicity Oxidative stress Neurodegeneration |
| title | Aluminum toxicity induced Alzheimer’s Disease and its potential treatment using antioxidants - a review |
| title_full | Aluminum toxicity induced Alzheimer’s Disease and its potential treatment using antioxidants - a review |
| title_fullStr | Aluminum toxicity induced Alzheimer’s Disease and its potential treatment using antioxidants - a review |
| title_full_unstemmed | Aluminum toxicity induced Alzheimer’s Disease and its potential treatment using antioxidants - a review |
| title_short | Aluminum toxicity induced Alzheimer’s Disease and its potential treatment using antioxidants - a review |
| title_sort | aluminum toxicity induced alzheimer s disease and its potential treatment using antioxidants a review |
| topic | Alzheimer’s Disease Aluminum Toxicity Oxidative stress Neurodegeneration |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100800&tlng=en |
| work_keys_str_mv | AT rishichoudhury aluminumtoxicityinducedalzheimersdiseaseanditspotentialtreatmentusingantioxidantsareview AT harshaashtekar aluminumtoxicityinducedalzheimersdiseaseanditspotentialtreatmentusingantioxidantsareview AT kartikbkhot aluminumtoxicityinducedalzheimersdiseaseanditspotentialtreatmentusingantioxidantsareview AT magritamalngiang aluminumtoxicityinducedalzheimersdiseaseanditspotentialtreatmentusingantioxidantsareview AT merugumoluvijaykumar aluminumtoxicityinducedalzheimersdiseaseanditspotentialtreatmentusingantioxidantsareview AT soumimandal aluminumtoxicityinducedalzheimersdiseaseanditspotentialtreatmentusingantioxidantsareview AT barnalidas aluminumtoxicityinducedalzheimersdiseaseanditspotentialtreatmentusingantioxidantsareview |