Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity

Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity

Abstract Background Pain is reported as the leading cause of disability in the common forms of inflammatory arthritis conditions. Acting as a key player in nociceptive processing, neuroinflammation, and neuron-glia communication, the chemokine CCL2/CCR2 axis holds great promise for controlling chron...

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Bibliographic Details
Main Authors: Marc-André Dansereau, Élora Midavaine, Valérie Bégin-Lavallée, Mounir Belkouch, Nicolas Beaudet, Jean-Michel Longpré, Stéphane Mélik-Parsadaniantz, Philippe Sarret
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Neuroinflammation
Subjects:
Nociceptor
INCB3344
Substance P
Nociception
MCP-1
CFA
Online Access:https://doi.org/10.1186/s12974-021-02125-y

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