Evaluation of the Efficacy of a New Commercially Available Inactivated Vaccine Against Ovine Enzootic Abortion
Ovine enzootic abortion (OEA), caused by Chlamydia abortus, is an economically important disease in many countries. Inactivated vaccines have been used for many years as they induce immunity in sheep, although outbreaks of abortions have been described in vaccinated flocks. In addition, there is a c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fvets.2020.00593/full |
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| author | Carlos Montbrau Mireia Fontseca Ricard March Marta Sitja Julio Benavides Nieves Ortega María Rosa Caro Jesús Salinas |
| author_facet | Carlos Montbrau Mireia Fontseca Ricard March Marta Sitja Julio Benavides Nieves Ortega María Rosa Caro Jesús Salinas |
| author_sort | Carlos Montbrau |
| collection | DOAJ |
| description | Ovine enzootic abortion (OEA), caused by Chlamydia abortus, is an economically important disease in many countries. Inactivated vaccines have been used for many years as they induce immunity in sheep, although outbreaks of abortions have been described in vaccinated flocks. In addition, there is a commercially available live attenuated vaccine that provides good protective results. Recently however, reports question the attenuation of this vaccine and associate it with the appearance of outbreaks of OEA in vaccinated flocks. In the present study, a recently commercialized inactivated vaccine (INMEVA®; Laboratorios Hipra S.A., Amer, Spain) has been evaluated using mouse and sheep experimental models. In the mouse models (non-pregnant and pregnant models), the efficacy of INMEVA vaccine has been compared to an unvaccinated control group and to an experimental inactivated vaccine considered as a positive protection control (UMU vaccine). In the non- pregnant model, the UMU vaccine was more effective than the INMEVA vaccine regarding the impact on body weight or the presence of C. abortus in the liver, but both vaccinated groups (UMU and INMEVA) had significantly lower C. abortus in the liver compared to the control group. In the pregnant model in terms of reproductive failures, pups per mouse or the presence of C. abortus in the liver or uterus, no significant differences were found between both vaccines, inducing protection compared to the control group. In the ovine pregnant model, where INMEVA vaccine was compared only to an unvaccinated group, the results indicate that this new commercial vaccine is safe and provides a suitable level of protection against an experimental challenge with C. abortus. A 75% reduction in reproductive disorders, 55% reduction in animals with C. abortus shedding on day of parturition/abortion, and a significant reduction of the average amount of chlamydial shedding from parturition/abortion over the next 21 days was observed, in relation to the infected control group. The results suggest that this vaccine is adequate for the control and prevention of OEA; however, future studies are necessary to elucidate the type of protective immune response that it induces. |
| first_indexed | 2024-04-12T08:09:15Z |
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| id | doaj.art-b7d1eef88df14594901e20ac7d6ba1a6 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-12T08:09:15Z |
| publishDate | 2020-09-01 |
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| spelling | doaj.art-b7d1eef88df14594901e20ac7d6ba1a62022-12-22T03:41:02ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692020-09-01710.3389/fvets.2020.00593568592Evaluation of the Efficacy of a New Commercially Available Inactivated Vaccine Against Ovine Enzootic AbortionCarlos Montbrau0Mireia Fontseca1Ricard March2Marta Sitja3Julio Benavides4Nieves Ortega5María Rosa Caro6Jesús Salinas7Hipra Scientific, S.L.U., Girona, SpainHipra Scientific, S.L.U., Girona, SpainHipra Scientific, S.L.U., Girona, SpainHipra Scientific, S.L.U., Girona, SpainInstituto de Ganadería de Montaña (CSIC-Universidad de León), León, SpainDepartment of Animal Health, Faculty of Veterinary, Mare Nostrum International University of Murcia, Murcia, SpainDepartment of Animal Health, Faculty of Veterinary, Mare Nostrum International University of Murcia, Murcia, SpainDepartment of Animal Health, Faculty of Veterinary, Mare Nostrum International University of Murcia, Murcia, SpainOvine enzootic abortion (OEA), caused by Chlamydia abortus, is an economically important disease in many countries. Inactivated vaccines have been used for many years as they induce immunity in sheep, although outbreaks of abortions have been described in vaccinated flocks. In addition, there is a commercially available live attenuated vaccine that provides good protective results. Recently however, reports question the attenuation of this vaccine and associate it with the appearance of outbreaks of OEA in vaccinated flocks. In the present study, a recently commercialized inactivated vaccine (INMEVA®; Laboratorios Hipra S.A., Amer, Spain) has been evaluated using mouse and sheep experimental models. In the mouse models (non-pregnant and pregnant models), the efficacy of INMEVA vaccine has been compared to an unvaccinated control group and to an experimental inactivated vaccine considered as a positive protection control (UMU vaccine). In the non- pregnant model, the UMU vaccine was more effective than the INMEVA vaccine regarding the impact on body weight or the presence of C. abortus in the liver, but both vaccinated groups (UMU and INMEVA) had significantly lower C. abortus in the liver compared to the control group. In the pregnant model in terms of reproductive failures, pups per mouse or the presence of C. abortus in the liver or uterus, no significant differences were found between both vaccines, inducing protection compared to the control group. In the ovine pregnant model, where INMEVA vaccine was compared only to an unvaccinated group, the results indicate that this new commercial vaccine is safe and provides a suitable level of protection against an experimental challenge with C. abortus. A 75% reduction in reproductive disorders, 55% reduction in animals with C. abortus shedding on day of parturition/abortion, and a significant reduction of the average amount of chlamydial shedding from parturition/abortion over the next 21 days was observed, in relation to the infected control group. The results suggest that this vaccine is adequate for the control and prevention of OEA; however, future studies are necessary to elucidate the type of protective immune response that it induces.https://www.frontiersin.org/article/10.3389/fvets.2020.00593/fullChlamydia abortusovine enzootic abortionsheepvaccineabortion |
| spellingShingle | Carlos Montbrau Mireia Fontseca Ricard March Marta Sitja Julio Benavides Nieves Ortega María Rosa Caro Jesús Salinas Evaluation of the Efficacy of a New Commercially Available Inactivated Vaccine Against Ovine Enzootic Abortion Frontiers in Veterinary Science Chlamydia abortus ovine enzootic abortion sheep vaccine abortion |
| title | Evaluation of the Efficacy of a New Commercially Available Inactivated Vaccine Against Ovine Enzootic Abortion |
| title_full | Evaluation of the Efficacy of a New Commercially Available Inactivated Vaccine Against Ovine Enzootic Abortion |
| title_fullStr | Evaluation of the Efficacy of a New Commercially Available Inactivated Vaccine Against Ovine Enzootic Abortion |
| title_full_unstemmed | Evaluation of the Efficacy of a New Commercially Available Inactivated Vaccine Against Ovine Enzootic Abortion |
| title_short | Evaluation of the Efficacy of a New Commercially Available Inactivated Vaccine Against Ovine Enzootic Abortion |
| title_sort | evaluation of the efficacy of a new commercially available inactivated vaccine against ovine enzootic abortion |
| topic | Chlamydia abortus ovine enzootic abortion sheep vaccine abortion |
| url | https://www.frontiersin.org/article/10.3389/fvets.2020.00593/full |
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