Innate and Acquired Cellular Immunity in Children with Familial Hypercholesterolemia Treated with Simvastatin
The aim of this cross-sectional study was to assess the influence of simvastatin treatment in children with familial hypercholesterolemia (FH) on parameters of cellular immunity. Twenty-six children with FH were included, of which thirteen were treated with 10 mg simvastatin for at least 26 weeks, a...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/10/2924 |
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| author | Radosław Motkowski Marek Alifier Paweł Abramowicz Jerzy Konstantynowicz Bożena Mikołuć Anna Stasiak-Barmuta |
| author_facet | Radosław Motkowski Marek Alifier Paweł Abramowicz Jerzy Konstantynowicz Bożena Mikołuć Anna Stasiak-Barmuta |
| author_sort | Radosław Motkowski |
| collection | DOAJ |
| description | The aim of this cross-sectional study was to assess the influence of simvastatin treatment in children with familial hypercholesterolemia (FH) on parameters of cellular immunity. Twenty-six children with FH were included, of which thirteen were treated with 10 mg simvastatin for at least 26 weeks, and thirteen were age- and sex-matched with a low-cholesterol diet only. Total WBC count and lipid profile were measured. Flow cytometry was used to identify lymphocyte subsets and determine the expression of adhesion molecules (AM) and toll-like receptors (TLRs) on leukocytes. No differences were found in the basic values of peripheral blood count and subpopulations of lymphocytes between groups. The percentage of granulocytes with the expression of AM was higher in those treated with statins. The TLR-2 expression on granulocytes and monocytes showed higher values, whereas the TLR-4 expression was lower on lymphocytes and granulocytes in simvastatin-treated children. Treatment with simvastatin in children with FH is not associated with alterations in the amounts of granulocytes and monocytes. There is no association between statin treatment and the pattern of peripheral blood lymphocyte subpopulations. The role of AM and TLRs needs further investigation, given the effect of statins on the innate immunity may be important for their efficacy and safety during growth. |
| first_indexed | 2024-03-10T03:39:54Z |
| format | Article |
| id | doaj.art-b7d2b06c8f2a4461949f1473caf60332 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:39:54Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b7d2b06c8f2a4461949f1473caf603322023-11-23T11:36:58ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011110292410.3390/jcm11102924Innate and Acquired Cellular Immunity in Children with Familial Hypercholesterolemia Treated with SimvastatinRadosław Motkowski0Marek Alifier1Paweł Abramowicz2Jerzy Konstantynowicz3Bożena Mikołuć4Anna Stasiak-Barmuta5Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Clinical Immunology, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Clinical Immunology, Medical University of Bialystok, 15-274 Bialystok, PolandThe aim of this cross-sectional study was to assess the influence of simvastatin treatment in children with familial hypercholesterolemia (FH) on parameters of cellular immunity. Twenty-six children with FH were included, of which thirteen were treated with 10 mg simvastatin for at least 26 weeks, and thirteen were age- and sex-matched with a low-cholesterol diet only. Total WBC count and lipid profile were measured. Flow cytometry was used to identify lymphocyte subsets and determine the expression of adhesion molecules (AM) and toll-like receptors (TLRs) on leukocytes. No differences were found in the basic values of peripheral blood count and subpopulations of lymphocytes between groups. The percentage of granulocytes with the expression of AM was higher in those treated with statins. The TLR-2 expression on granulocytes and monocytes showed higher values, whereas the TLR-4 expression was lower on lymphocytes and granulocytes in simvastatin-treated children. Treatment with simvastatin in children with FH is not associated with alterations in the amounts of granulocytes and monocytes. There is no association between statin treatment and the pattern of peripheral blood lymphocyte subpopulations. The role of AM and TLRs needs further investigation, given the effect of statins on the innate immunity may be important for their efficacy and safety during growth.https://www.mdpi.com/2077-0383/11/10/2924atherosclerosisstatinsflow cytometryadhesion moleculeschildrenfamilial hypercholesterolemia |
| spellingShingle | Radosław Motkowski Marek Alifier Paweł Abramowicz Jerzy Konstantynowicz Bożena Mikołuć Anna Stasiak-Barmuta Innate and Acquired Cellular Immunity in Children with Familial Hypercholesterolemia Treated with Simvastatin Journal of Clinical Medicine atherosclerosis statins flow cytometry adhesion molecules children familial hypercholesterolemia |
| title | Innate and Acquired Cellular Immunity in Children with Familial Hypercholesterolemia Treated with Simvastatin |
| title_full | Innate and Acquired Cellular Immunity in Children with Familial Hypercholesterolemia Treated with Simvastatin |
| title_fullStr | Innate and Acquired Cellular Immunity in Children with Familial Hypercholesterolemia Treated with Simvastatin |
| title_full_unstemmed | Innate and Acquired Cellular Immunity in Children with Familial Hypercholesterolemia Treated with Simvastatin |
| title_short | Innate and Acquired Cellular Immunity in Children with Familial Hypercholesterolemia Treated with Simvastatin |
| title_sort | innate and acquired cellular immunity in children with familial hypercholesterolemia treated with simvastatin |
| topic | atherosclerosis statins flow cytometry adhesion molecules children familial hypercholesterolemia |
| url | https://www.mdpi.com/2077-0383/11/10/2924 |
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