Effect of Curcumin on Oral Lichen Planus: A Single Blind Randomized Controlled Clinical Trial
Background and purpose: Lichen planus management requires introducing effective local herbal ingredients and cost-effective treatments with fewer side effects compared with corticosteroids. Due to current condition and restrictions in making chemical drugs this study was done to investigate the effe...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2022-08-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-17434-en.html |
| _version_ | 1797893246021533696 |
|---|---|
| author | Nazanin Ghobadi Simin Lesan Mandana Khatibi |
| author_facet | Nazanin Ghobadi Simin Lesan Mandana Khatibi |
| author_sort | Nazanin Ghobadi |
| collection | DOAJ |
| description | Background and purpose: Lichen planus management requires introducing effective local herbal ingredients and cost-effective treatments with fewer side effects compared with corticosteroids. Due to current condition and restrictions in making chemical drugs this study was done to investigate the effect of curcumin on oral lichen planus.
Materials and methods: In a randomized controlled clinical trial, 28 patients with oral lichen planus were selected sequentially and were randomly divided into an intervention group and a placebo group (n= 14 per group). Patients in intervention group received topical corticosteroid, antifungal medication, and one Sina Curcumin capsule for a month. In placebo group, the patients were given corticosteroid, antifungal medication, and one placebo capsule for the same duration.
Results: There were significant differences in appearance of lesions and pain before treatment (P=0.227 and P=0.769, respectively), two weeks after treatment (P=0.031 and P= 0.0497), and four weeks after treatment (P=0.0001 and P= 0.019). Lesion size did not show significant differences between the two groups before (P=0.349), two weeks after (P=0.213), and four weeks after treatment (P=0.123).
Conclusion: In the present study, pain and appearance of lesions improved in intervention group but lesion size was not found to improve significantly. According to current study, curcumin can be considered as an effective agent in treatment of oral lichen planus. |
| first_indexed | 2024-04-10T06:49:48Z |
| format | Article |
| id | doaj.art-b7d348b981704533a0354c198b371063 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T06:49:48Z |
| publishDate | 2022-08-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-b7d348b981704533a0354c198b3710632023-02-28T08:50:45ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792022-08-01322113748Effect of Curcumin on Oral Lichen Planus: A Single Blind Randomized Controlled Clinical TrialNazanin Ghobadi0Simin Lesan1Mandana Khatibi2 Assistant Professor, Department of Oral and Maxillofacial Diseases, Faculty of Dentistry, Bushehr University of Medical Sciences, Bushehr, Iran Associate Professor, Department of Oral and Maxillofacial Diseases, Faculty of Dentistry Islamic Azad University, Tehran Medical Branch, Tehran, Iran Assistant Professor, Department of Oral and Maxillofacial Diseases, Faculty of Dentistry, Islamic Azad University, Tehran Medical Branch, Tehran, Iran Background and purpose: Lichen planus management requires introducing effective local herbal ingredients and cost-effective treatments with fewer side effects compared with corticosteroids. Due to current condition and restrictions in making chemical drugs this study was done to investigate the effect of curcumin on oral lichen planus. Materials and methods: In a randomized controlled clinical trial, 28 patients with oral lichen planus were selected sequentially and were randomly divided into an intervention group and a placebo group (n= 14 per group). Patients in intervention group received topical corticosteroid, antifungal medication, and one Sina Curcumin capsule for a month. In placebo group, the patients were given corticosteroid, antifungal medication, and one placebo capsule for the same duration. Results: There were significant differences in appearance of lesions and pain before treatment (P=0.227 and P=0.769, respectively), two weeks after treatment (P=0.031 and P= 0.0497), and four weeks after treatment (P=0.0001 and P= 0.019). Lesion size did not show significant differences between the two groups before (P=0.349), two weeks after (P=0.213), and four weeks after treatment (P=0.123). Conclusion: In the present study, pain and appearance of lesions improved in intervention group but lesion size was not found to improve significantly. According to current study, curcumin can be considered as an effective agent in treatment of oral lichen planus.http://jmums.mazums.ac.ir/article-1-17434-en.htmlcurcuminoral lichen planuscorticosteroid |
| spellingShingle | Nazanin Ghobadi Simin Lesan Mandana Khatibi Effect of Curcumin on Oral Lichen Planus: A Single Blind Randomized Controlled Clinical Trial Journal of Mazandaran University of Medical Sciences curcumin oral lichen planus corticosteroid |
| title | Effect of Curcumin on Oral Lichen Planus: A Single Blind Randomized Controlled Clinical Trial |
| title_full | Effect of Curcumin on Oral Lichen Planus: A Single Blind Randomized Controlled Clinical Trial |
| title_fullStr | Effect of Curcumin on Oral Lichen Planus: A Single Blind Randomized Controlled Clinical Trial |
| title_full_unstemmed | Effect of Curcumin on Oral Lichen Planus: A Single Blind Randomized Controlled Clinical Trial |
| title_short | Effect of Curcumin on Oral Lichen Planus: A Single Blind Randomized Controlled Clinical Trial |
| title_sort | effect of curcumin on oral lichen planus a single blind randomized controlled clinical trial |
| topic | curcumin oral lichen planus corticosteroid |
| url | http://jmums.mazums.ac.ir/article-1-17434-en.html |
| work_keys_str_mv | AT nazaninghobadi effectofcurcuminonorallichenplanusasingleblindrandomizedcontrolledclinicaltrial AT siminlesan effectofcurcuminonorallichenplanusasingleblindrandomizedcontrolledclinicaltrial AT mandanakhatibi effectofcurcuminonorallichenplanusasingleblindrandomizedcontrolledclinicaltrial |