Beyond the G protein α subunit: investigating the functional impact of other components of the Gαi3 heterotrimers

Beyond the G protein α subunit: investigating the functional impact of other components of the Gαi3 heterotrimers

Abstract Background Specific interactions between G protein-coupled receptors (GPCRs) and G proteins play a key role in mediating signaling events. While there is little doubt regarding receptor preference for Gα subunits, the preferences for specific Gβ and Gγ subunits and the effects of different...

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Bibliographic Details
Main Authors: Beata Rysiewicz, Ewa Błasiak, Paweł Mystek, Marta Dziedzicka-Wasylewska, Agnieszka Polit
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cell Communication and Signaling
Subjects:
Heterotrimeric G proteins
Dopamine D2 receptor
GPCR
Gαi3 subunit
Gβγ dimer
Subcellular localization
Online Access:https://doi.org/10.1186/s12964-023-01307-w

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