Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification
The considerable development of carrier-free nanodrugs has been achieved due to their high drug-loading capability, simple preparation method, and offering “all-in-one” functional platform features. However, the native defects of carrier-free nanodrugs limit their delivery and release behavior throu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2022-02-01
|
| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21003212 |
| _version_ | 1827279613855793152 |
|---|---|
| author | Heng Mei Shengsheng Cai Dennis Huang Huile Gao Jun Cao Bin He |
| author_facet | Heng Mei Shengsheng Cai Dennis Huang Huile Gao Jun Cao Bin He |
| author_sort | Heng Mei |
| collection | DOAJ |
| description | The considerable development of carrier-free nanodrugs has been achieved due to their high drug-loading capability, simple preparation method, and offering “all-in-one” functional platform features. However, the native defects of carrier-free nanodrugs limit their delivery and release behavior throughout the in vivo journey, which significantly compromise the therapeutic efficacy and hinder their further development in cancer treatment. In this review, we summarized and discussed the recent strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy, including optimizing the intrinsic physicochemical properties and external modification. Finally, the corresponding challenges that carrier-free nanodrugs faced are discussed and the future perspectives for its application are presented. We hope this review will provide constructive information for the rational design of more effective carrier-free nanodrugs to advance therapeutic treatment. |
| first_indexed | 2024-04-24T08:21:49Z |
| format | Article |
| id | doaj.art-b7d73b4049954ea78e1ebb803ed5e4b8 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:21:49Z |
| publishDate | 2022-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-b7d73b4049954ea78e1ebb803ed5e4b82024-04-17T00:51:56ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-02-018220240Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modificationHeng Mei0Shengsheng Cai1Dennis Huang2Huile Gao3Jun Cao4Bin He5National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78731, USAWest China School of Pharmacy, Sichuan University, Chengdu, 610064, China; Corresponding author.National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; Corresponding author.National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaThe considerable development of carrier-free nanodrugs has been achieved due to their high drug-loading capability, simple preparation method, and offering “all-in-one” functional platform features. However, the native defects of carrier-free nanodrugs limit their delivery and release behavior throughout the in vivo journey, which significantly compromise the therapeutic efficacy and hinder their further development in cancer treatment. In this review, we summarized and discussed the recent strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy, including optimizing the intrinsic physicochemical properties and external modification. Finally, the corresponding challenges that carrier-free nanodrugs faced are discussed and the future perspectives for its application are presented. We hope this review will provide constructive information for the rational design of more effective carrier-free nanodrugs to advance therapeutic treatment.http://www.sciencedirect.com/science/article/pii/S2452199X21003212Carrier-free nanodrugsDrug delivery and releaseIntrinsic physicochemical propertiesExternal modificationTherapeutic efficacy |
| spellingShingle | Heng Mei Shengsheng Cai Dennis Huang Huile Gao Jun Cao Bin He Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification Bioactive Materials Carrier-free nanodrugs Drug delivery and release Intrinsic physicochemical properties External modification Therapeutic efficacy |
| title | Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification |
| title_full | Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification |
| title_fullStr | Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification |
| title_full_unstemmed | Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification |
| title_short | Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification |
| title_sort | carrier free nanodrugs with efficient drug delivery and release for cancer therapy from intrinsic physicochemical properties to external modification |
| topic | Carrier-free nanodrugs Drug delivery and release Intrinsic physicochemical properties External modification Therapeutic efficacy |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21003212 |
| work_keys_str_mv | AT hengmei carrierfreenanodrugswithefficientdrugdeliveryandreleaseforcancertherapyfromintrinsicphysicochemicalpropertiestoexternalmodification AT shengshengcai carrierfreenanodrugswithefficientdrugdeliveryandreleaseforcancertherapyfromintrinsicphysicochemicalpropertiestoexternalmodification AT dennishuang carrierfreenanodrugswithefficientdrugdeliveryandreleaseforcancertherapyfromintrinsicphysicochemicalpropertiestoexternalmodification AT huilegao carrierfreenanodrugswithefficientdrugdeliveryandreleaseforcancertherapyfromintrinsicphysicochemicalpropertiestoexternalmodification AT juncao carrierfreenanodrugswithefficientdrugdeliveryandreleaseforcancertherapyfromintrinsicphysicochemicalpropertiestoexternalmodification AT binhe carrierfreenanodrugswithefficientdrugdeliveryandreleaseforcancertherapyfromintrinsicphysicochemicalpropertiestoexternalmodification |