Predicting glucocorticoid effectiveness in thyroid eye disease: combined value from serological lipid metabolism and an orbital MRI parameter
Purpose: The aim was to determine the combined value of serological lipid metabolism and an orbital MRI quantitative parameter in predicting the effectiveness of glucocorticoid (GC) therapy in patients with thyroid eye disease (TED). Methods: This study retrospectively enrolled 46 patients with ac...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2024-01-01
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| Series: | European Thyroid Journal |
| Subjects: | |
| Online Access: | https://etj.bioscientifica.com/view/journals/etj/13/1/ETJ-23-0109.xml |
| _version_ | 1827349677808287744 |
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| author | Haitao Zhang Hao Hu Yueyue Wang Xinjie Duan Lu Chen Jiang Zhou Wen Chen Weizhong Zhang Xiaoquan Xu Huanhuan Chen |
| author_facet | Haitao Zhang Hao Hu Yueyue Wang Xinjie Duan Lu Chen Jiang Zhou Wen Chen Weizhong Zhang Xiaoquan Xu Huanhuan Chen |
| author_sort | Haitao Zhang |
| collection | DOAJ |
| description | Purpose: The aim was to determine the combined value of serological lipid metabolism and an orbital MRI quantitative parameter in predicting the effectiveness of glucocorticoid (GC) therapy in patients with thyroid eye disease (TED).
Methods: This study retrospectively enrolled 46 patients with active and moderate-to-severe TED (GC-effective group, n = 29; GC-ineffective group, n = 17). Serological lipid metabolism, the orbital MRI-based minimum signal intensity ratio of extraocular muscles (EOM-SIRmin), as well as other clinical parameters before GC therapy were collected and compared between the two groups. Multivariate logistic regression and receiver operating characteristic curve analysis were adopted to identify independent predictable variables and assess their predictive performances.
Results: Compared to the GC-ineffective group, the GC-effective group showed lower serum total cholesterol levels (P = 0.006), lower serum low-density lipoprotein cholesterol levels (P = 0.019), higher EOM-SIRmin values (P = 0.005), and shorter disease durations (P = 0.017). Serum total cholesterol and EOM-SIRmin were found to be independent predictors of GC-effective TED through multivariate analysis (odds ratios = 0.253 and 2.036 per 0.1 units, respectively) (both P < 0.05). The integration of serum total cholesterol ≤4.8 mmol/L and EOM-SIRmin ≥ 1.12 had a better predictive efficacy (area under the curve, 0.834) than EOM-SIRmin alone, with a sensitivity of 75.9% and a specificity of 82.4% (P = 0.031).
Conclusion: Serological lipid metabolism, combined with an orbital MRI-derived parameter, was a useful marker for predicting the effectiveness of GCs in patients with active and moderate-to-severe TED. |
| first_indexed | 2024-03-08T00:45:26Z |
| format | Article |
| id | doaj.art-b7d9176ee53441b0a24f4c11210dbfbf |
| institution | Directory Open Access Journal |
| issn | 2235-0802 |
| language | English |
| last_indexed | 2024-03-08T00:45:26Z |
| publishDate | 2024-01-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | European Thyroid Journal |
| spelling | doaj.art-b7d9176ee53441b0a24f4c11210dbfbf2024-02-15T12:36:56ZengBioscientificaEuropean Thyroid Journal2235-08022024-01-01131110https://doi.org/10.1530/ETJ-23-0109Predicting glucocorticoid effectiveness in thyroid eye disease: combined value from serological lipid metabolism and an orbital MRI parameterHaitao Zhang0Hao Hu1Yueyue Wang2Xinjie Duan3Lu Chen4Jiang Zhou5Wen Chen6Weizhong Zhang7Xiaoquan Xu8Huanhuan Chen9Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Ophthalmology, The Friendship Hospital of Ili Kazakh Autonomous Prefecture Ili & Jiangsu Joint Institute of Health, Ili, China; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaPurpose: The aim was to determine the combined value of serological lipid metabolism and an orbital MRI quantitative parameter in predicting the effectiveness of glucocorticoid (GC) therapy in patients with thyroid eye disease (TED). Methods: This study retrospectively enrolled 46 patients with active and moderate-to-severe TED (GC-effective group, n = 29; GC-ineffective group, n = 17). Serological lipid metabolism, the orbital MRI-based minimum signal intensity ratio of extraocular muscles (EOM-SIRmin), as well as other clinical parameters before GC therapy were collected and compared between the two groups. Multivariate logistic regression and receiver operating characteristic curve analysis were adopted to identify independent predictable variables and assess their predictive performances. Results: Compared to the GC-ineffective group, the GC-effective group showed lower serum total cholesterol levels (P = 0.006), lower serum low-density lipoprotein cholesterol levels (P = 0.019), higher EOM-SIRmin values (P = 0.005), and shorter disease durations (P = 0.017). Serum total cholesterol and EOM-SIRmin were found to be independent predictors of GC-effective TED through multivariate analysis (odds ratios = 0.253 and 2.036 per 0.1 units, respectively) (both P < 0.05). The integration of serum total cholesterol ≤4.8 mmol/L and EOM-SIRmin ≥ 1.12 had a better predictive efficacy (area under the curve, 0.834) than EOM-SIRmin alone, with a sensitivity of 75.9% and a specificity of 82.4% (P = 0.031). Conclusion: Serological lipid metabolism, combined with an orbital MRI-derived parameter, was a useful marker for predicting the effectiveness of GCs in patients with active and moderate-to-severe TED.https://etj.bioscientifica.com/view/journals/etj/13/1/ETJ-23-0109.xmlthyroid eye diseaseglucocorticoid therapyeffectivenessserological lipid metabolismmri |
| spellingShingle | Haitao Zhang Hao Hu Yueyue Wang Xinjie Duan Lu Chen Jiang Zhou Wen Chen Weizhong Zhang Xiaoquan Xu Huanhuan Chen Predicting glucocorticoid effectiveness in thyroid eye disease: combined value from serological lipid metabolism and an orbital MRI parameter European Thyroid Journal thyroid eye disease glucocorticoid therapy effectiveness serological lipid metabolism mri |
| title | Predicting glucocorticoid effectiveness in thyroid eye disease: combined value from serological lipid metabolism and an orbital MRI parameter |
| title_full | Predicting glucocorticoid effectiveness in thyroid eye disease: combined value from serological lipid metabolism and an orbital MRI parameter |
| title_fullStr | Predicting glucocorticoid effectiveness in thyroid eye disease: combined value from serological lipid metabolism and an orbital MRI parameter |
| title_full_unstemmed | Predicting glucocorticoid effectiveness in thyroid eye disease: combined value from serological lipid metabolism and an orbital MRI parameter |
| title_short | Predicting glucocorticoid effectiveness in thyroid eye disease: combined value from serological lipid metabolism and an orbital MRI parameter |
| title_sort | predicting glucocorticoid effectiveness in thyroid eye disease combined value from serological lipid metabolism and an orbital mri parameter |
| topic | thyroid eye disease glucocorticoid therapy effectiveness serological lipid metabolism mri |
| url | https://etj.bioscientifica.com/view/journals/etj/13/1/ETJ-23-0109.xml |
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