Monocyte progenitors give rise to multinucleated giant cells
Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22103-5 |
| _version_ | 1818750639935586304 |
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| author | Anne Kathrin Lösslein Florens Lohrmann Lisa Scheuermann Kourosh Gharun Jana Neuber Julia Kolter Aaron James Forde Christian Kleimeyer Ying Yee Poh Matthias Mack Antigoni Triantafyllopoulou Micah D. Dunlap Shabaana A. Khader Maximilian Seidl Alexandra Hölscher Christoph Hölscher Xue Li Guan Anca Dorhoi Philipp Henneke |
| author_facet | Anne Kathrin Lösslein Florens Lohrmann Lisa Scheuermann Kourosh Gharun Jana Neuber Julia Kolter Aaron James Forde Christian Kleimeyer Ying Yee Poh Matthias Mack Antigoni Triantafyllopoulou Micah D. Dunlap Shabaana A. Khader Maximilian Seidl Alexandra Hölscher Christoph Hölscher Xue Li Guan Anca Dorhoi Philipp Henneke |
| author_sort | Anne Kathrin Lösslein |
| collection | DOAJ |
| description | Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment. |
| first_indexed | 2024-12-18T04:22:53Z |
| format | Article |
| id | doaj.art-b7de3fe7ad2f4ec7a67aa8fc0ad6eba6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:22:53Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b7de3fe7ad2f4ec7a67aa8fc0ad6eba62022-12-21T21:21:11ZengNature PortfolioNature Communications2041-17232021-04-0112112210.1038/s41467-021-22103-5Monocyte progenitors give rise to multinucleated giant cellsAnne Kathrin Lösslein0Florens Lohrmann1Lisa Scheuermann2Kourosh Gharun3Jana Neuber4Julia Kolter5Aaron James Forde6Christian Kleimeyer7Ying Yee Poh8Matthias Mack9Antigoni Triantafyllopoulou10Micah D. Dunlap11Shabaana A. Khader12Maximilian Seidl13Alexandra Hölscher14Christoph Hölscher15Xue Li Guan16Anca Dorhoi17Philipp Henneke18Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of FreiburgInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of FreiburgMax Planck Institute for Infection BiologyInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of FreiburgInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of FreiburgInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of FreiburgInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of FreiburgInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of FreiburgNanyang Technological University, Lee Kong Chian School of MedicineUniversity Hospital Regensburg, Internal Medicine II, NephrologyInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of FreiburgDepartment of Molecular Microbiology, Washington University in St. Louis School of MedicineDepartment of Molecular Microbiology, Washington University in St. Louis School of MedicineCenter for Chronic Immunodeficiency and Institute for Clinical Pathology, Department of Pathology, Medical Center and Faculty of Medicine, Freiburg, Germany and Institute of Pathology, Heinrich Heine University and University Hospital of DuesseldorfForschungszentrum Borstel, Leibniz LungenzentrumForschungszentrum Borstel, Leibniz LungenzentrumNanyang Technological University, Lee Kong Chian School of MedicineMax Planck Institute for Infection BiologyInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of FreiburgMultinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.https://doi.org/10.1038/s41467-021-22103-5 |
| spellingShingle | Anne Kathrin Lösslein Florens Lohrmann Lisa Scheuermann Kourosh Gharun Jana Neuber Julia Kolter Aaron James Forde Christian Kleimeyer Ying Yee Poh Matthias Mack Antigoni Triantafyllopoulou Micah D. Dunlap Shabaana A. Khader Maximilian Seidl Alexandra Hölscher Christoph Hölscher Xue Li Guan Anca Dorhoi Philipp Henneke Monocyte progenitors give rise to multinucleated giant cells Nature Communications |
| title | Monocyte progenitors give rise to multinucleated giant cells |
| title_full | Monocyte progenitors give rise to multinucleated giant cells |
| title_fullStr | Monocyte progenitors give rise to multinucleated giant cells |
| title_full_unstemmed | Monocyte progenitors give rise to multinucleated giant cells |
| title_short | Monocyte progenitors give rise to multinucleated giant cells |
| title_sort | monocyte progenitors give rise to multinucleated giant cells |
| url | https://doi.org/10.1038/s41467-021-22103-5 |
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