Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study
Introduction: Heart failure (HF) and cancer are currently the leading causes of death worldwide, with an increasing incidence with age. Little is known about the treatment received and the prognosis of patients with acute HF and a prior cancer diagnosis. Objective: to determine the clinical characte...
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/3/571 |
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| author | Manuel Méndez-Bailón Noel Lorenzo-Villalba Miriam Romero-Correa Esther Guisado-Espartero Juan González-Soler Jessica Rugeles-Niño Angel Sebastián-Leza Luis Ceresuela-Eito Verónica Romaní-Costa Angustias Quesada-Simón Llanos Soler-Rangel Almudena Herrero-Domingo Luis Díez-García José Alcalá-Pedrajas María Villalonga-Comas Emmanuel Andrès Diego Gudiñ-Aguirre Francesc Formiga Oscar Aramburu-Bodas Jose Arias-Jiménez Prado Salamanca-Bautista on behalf of EPICTER Study Group |
| author_facet | Manuel Méndez-Bailón Noel Lorenzo-Villalba Miriam Romero-Correa Esther Guisado-Espartero Juan González-Soler Jessica Rugeles-Niño Angel Sebastián-Leza Luis Ceresuela-Eito Verónica Romaní-Costa Angustias Quesada-Simón Llanos Soler-Rangel Almudena Herrero-Domingo Luis Díez-García José Alcalá-Pedrajas María Villalonga-Comas Emmanuel Andrès Diego Gudiñ-Aguirre Francesc Formiga Oscar Aramburu-Bodas Jose Arias-Jiménez Prado Salamanca-Bautista on behalf of EPICTER Study Group |
| author_sort | Manuel Méndez-Bailón |
| collection | DOAJ |
| description | Introduction: Heart failure (HF) and cancer are currently the leading causes of death worldwide, with an increasing incidence with age. Little is known about the treatment received and the prognosis of patients with acute HF and a prior cancer diagnosis. Objective: to determine the clinical characteristics, palliative treatment received, and prognostic impact of patients with acute HF and a history of solid tumor. Methods: The EPICTER study (“Epidemiological survey of advanced heart failure”) is a cross-sectional, multicenter project that consecutively collected patients admitted for acute HF in 74 Spanish hospitals. Patients were classified into two groups according to whether they met criteria for acute HF with and without solid cancer, and the groups were subsequently compared. A multivariable logistic regression analysis was conducted, using the forward stepwise method. A Kaplan–Meier survival analysis was performed to evaluate the impact of solid tumor on prognosis in patients with acute HF. Results: A total of 3127 patients were included, of which 394 patients (13%) had a prior diagnosis of some type of solid cancer. Patients with a history of cancer presented a greater frequency of weight loss at admission: 18% vs. 12% (<i>p</i> = 0.030). In the cancer group, functional impairment was noted more frequently: 43% vs. 35%, <i>p</i> = 0.039). Patients with a history of solid cancer more frequently presented with acute HF with preserved ejection fraction (65% vs. 58%, <i>p</i> = 0.048) than reduced or mildly reduced. In-hospital and 6-month follow-up mortality was 31% (110/357) in patients with solid cancer vs. 26% (637/2466), <i>p</i> = 0.046. Conclusion: Our investigation demonstrates that in-hospital mortality and mortality during 6-month follow-up in patients with acute HF were higher in those subjects with a history of concomitant solid tumor cancer diagnosis. |
| first_indexed | 2024-03-09T23:42:13Z |
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| language | English |
| last_indexed | 2024-03-09T23:42:13Z |
| publishDate | 2022-01-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-b7e22bc4b2a7414e850395f1549965192023-11-23T16:50:33ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111357110.3390/jcm11030571Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER StudyManuel Méndez-Bailón0Noel Lorenzo-Villalba1Miriam Romero-Correa2Esther Guisado-Espartero3Juan González-Soler4Jessica Rugeles-Niño5Angel Sebastián-Leza6Luis Ceresuela-Eito7Verónica Romaní-Costa8Angustias Quesada-Simón9Llanos Soler-Rangel10Almudena Herrero-Domingo11Luis Díez-García12José Alcalá-Pedrajas13María Villalonga-Comas14Emmanuel Andrès15Diego Gudiñ-Aguirre16Francesc Formiga17Oscar Aramburu-Bodas18Jose Arias-Jiménez19Prado Salamanca-Bautista20on behalf of EPICTER Study GroupHospital Clínico Universitario San Carlos, Instituto de Investigación Sanitaria (IdISSC), 28040 Madrid, SpainService de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, FranceHospital General de Riotinto, 21660 Huelva, SpainInternal Medicine Department, Infanta Margarita Hospital, 14940 Cabra, Córdoba, SpainComplejo Hospitalario Universitario de Ourense, 32005 Ourense, SpainHospital Universitario Central de Asturias, 33011 Oviedo, SpainHospital Universitario de Cruces-Barakaldo, 48903 Bizkaia, SpainHospital del Baix Llobregat, 08970 Barcelona, SpainHospital Mutua de Terrassa, 08221 Barcelona, SpainHospital Universitario La Paz, 28046 Madrid, SpainHospital Universitario Infanta Sofía, 28703 Madrid, SpainHospital General Nuestra Señora del Prado, 45600 Toledo, SpainInternal Medicine Department, Torrecárdenas Hospital, 04009 Almería, SpainInternal Medicine Department, Pozoblanco Hospital, 14400 Pozoblanco, Córdoba, SpainHospital Universitario Son Espases, 07120 Palma de Mallorca, SpainService de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, FranceHospital Universitario Nuestra Señora de Candelaria, 38010 Tenerife, SpainHospital Universitario de Bellvitge, 08907 Barcelona, SpainHospital Universitario Virgen Macarena, 41009 Sevilla, SpainHospital Universitario Virgen Macarena, 41009 Sevilla, SpainHospital Universitario Virgen Macarena, 41009 Sevilla, SpainIntroduction: Heart failure (HF) and cancer are currently the leading causes of death worldwide, with an increasing incidence with age. Little is known about the treatment received and the prognosis of patients with acute HF and a prior cancer diagnosis. Objective: to determine the clinical characteristics, palliative treatment received, and prognostic impact of patients with acute HF and a history of solid tumor. Methods: The EPICTER study (“Epidemiological survey of advanced heart failure”) is a cross-sectional, multicenter project that consecutively collected patients admitted for acute HF in 74 Spanish hospitals. Patients were classified into two groups according to whether they met criteria for acute HF with and without solid cancer, and the groups were subsequently compared. A multivariable logistic regression analysis was conducted, using the forward stepwise method. A Kaplan–Meier survival analysis was performed to evaluate the impact of solid tumor on prognosis in patients with acute HF. Results: A total of 3127 patients were included, of which 394 patients (13%) had a prior diagnosis of some type of solid cancer. Patients with a history of cancer presented a greater frequency of weight loss at admission: 18% vs. 12% (<i>p</i> = 0.030). In the cancer group, functional impairment was noted more frequently: 43% vs. 35%, <i>p</i> = 0.039). Patients with a history of solid cancer more frequently presented with acute HF with preserved ejection fraction (65% vs. 58%, <i>p</i> = 0.048) than reduced or mildly reduced. In-hospital and 6-month follow-up mortality was 31% (110/357) in patients with solid cancer vs. 26% (637/2466), <i>p</i> = 0.046. Conclusion: Our investigation demonstrates that in-hospital mortality and mortality during 6-month follow-up in patients with acute HF were higher in those subjects with a history of concomitant solid tumor cancer diagnosis.https://www.mdpi.com/2077-0383/11/3/571acute heart failurecancermortality |
| spellingShingle | Manuel Méndez-Bailón Noel Lorenzo-Villalba Miriam Romero-Correa Esther Guisado-Espartero Juan González-Soler Jessica Rugeles-Niño Angel Sebastián-Leza Luis Ceresuela-Eito Verónica Romaní-Costa Angustias Quesada-Simón Llanos Soler-Rangel Almudena Herrero-Domingo Luis Díez-García José Alcalá-Pedrajas María Villalonga-Comas Emmanuel Andrès Diego Gudiñ-Aguirre Francesc Formiga Oscar Aramburu-Bodas Jose Arias-Jiménez Prado Salamanca-Bautista on behalf of EPICTER Study Group Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study Journal of Clinical Medicine acute heart failure cancer mortality |
| title | Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study |
| title_full | Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study |
| title_fullStr | Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study |
| title_full_unstemmed | Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study |
| title_short | Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study |
| title_sort | cancer impacts prognosis on mortality in patients with acute heart failure analysis of the epicter study |
| topic | acute heart failure cancer mortality |
| url | https://www.mdpi.com/2077-0383/11/3/571 |
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