IFNγ-Stimulated B Cells Inhibit T Follicular Helper Cells and Protect Against Atherosclerosis

IFNγ-Stimulated B Cells Inhibit T Follicular Helper Cells and Protect Against Atherosclerosis

B and T cells are interconnected in the T follicular helper—germinal center B cell (TFH-GC B cell) axis, which is hyperactive during atherosclerosis development and loss of control along this axis results in exacerbated atherosclerosis. Inhibition of the TFH–GC B cell axis can be achieved by providi...

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Bibliographic Details
Main Authors: Hidde Douna, J. de Mol, Jacob Amersfoort, Frank H. Schaftenaar, Mate G. Kiss, Bianca E. Suur, Mara J. Kroner, Christoph J. Binder, Ilze Bot, Gijs H. M. Van Puijvelde, Johan Kuiper, Amanda C. Foks
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiovascular disease
atherosclerosis
B cells
PD-L1
interferon-gamma
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.781436/full

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